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生物来源
Escherichia coli
质量水平
重组
expressed in E. coli
描述
200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).
产品线
BioReagent
方案
>97% (SDS-PAGE)
表单
lyophilized powder
效能
0.030-0.300 ng/mL EC50
分子量
predicted mol wt ~24 kDa
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
溶解性
water: 0.5000 mL, clear, colorless
UniProt登记号
运输
ambient
储存温度
−20°C
基因信息
human ... PRL(5617)
应用
可用在细胞培养应用中研究催乳素对细胞信号传导和基因表达的调节。
生化/生理作用
催乳素是一种神经内分泌激素。催乳激素受体是一种跨膜糖蛋白，属于细胞因子造血受体家族。大量细胞和器官表达该受体，包括 B 细胞、T 细胞、巨噬细胞、单核细胞和嗜中性粒细胞。催乳素信号转导涉及 JAK/STAT 家族和 src 激酶家族。引起泌乳；抑制促性腺激素的分泌；释放受多巴胺抑制。
神经内分泌激素；属于细胞因子造血受体家族；诱导泌乳；抑制促性腺激素的分泌；释放受多巴胺抑制。
其他说明
包含天然产物中不存在的 N 末端甲硫氨酸。
外形
从 10mM 磷酸盐和 50mM 氯化钠溶液（pH 8.0）中冻干。
重悬
建议将无菌 4 mM HCl（含 1 mg/mL 牛血清白蛋白）添加到小瓶中，以制备不低于 100 μg/mL 的储液。
分析说明
生物学活性是通过大鼠淋巴瘤细胞系 Nb2-11 的增殖实验测定的。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.
N Ben-Jonathan et al.
Endocrine reviews, 17(6), 639-669 (1996-12-01)
Regulatory action of prolactin on the in vitro growth of CD34+ve human hemopoietic progenitor cells.
G Bellone et al.
Journal of cellular physiology, 163(2), 221-231 (1995-05-01)
The pituitary hormone prolactin (Prl) is known to act as a local regulator of immune cell function, and Prl-binding receptors (Prl-R) have been described to share distinctive features with the members of the newly described cytokine/hemopoietin receptor superfamily. Here we
Julien Auffret et al.
American journal of physiology. Endocrinology and metabolism, 305(10), E1309-E1318 (2013-09-26)
Prolactin (PRL) and placental lactogens stimulate β-cell replication and insulin production in pancreatic islets and insulinoma cells through binding to the PRL receptor (PRLR). However, the contribution of PRLR signaling to β-cell ontogeny and function in perinatal life and the
Gerda de Kuijper et al.
Research in developmental disabilities, 34(9), 2799-2809 (2013-06-25)
Individuals with intellectual disability frequently use antipsychotics for many years. This may have detrimental health effects, including neurological symptoms and metabolic and hormonal dysregulation, the latter possibly affecting bone metabolism. There is large variability in the degree in which antipsychotic
Bibiana Moreno-Carranza et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(7), R720-R726 (2013-08-21)
Prolactin (PRL) is a potent liver mitogen and proangiogenic hormone. Here, we used hyperprolactinemic rats and PRL receptor-null mice (PRLR(-/-)) to study the effect of PRL on liver growth and angiogenesis before and after partial hepatectomy (PH). Liver-to-body weight ratio
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