L1170

LY-487379 hydrochloride

≥98% (HPLC)

• 别名: N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine hydrochloride
• 经验公式（希尔记法）: C₂₁H₁₉F₃N₂O₄SHCl
• CAS号: 353229-59-1
• 分子量: 488.91
• MDL编号: MFCD11519970
• UNSPSC代码: 12352209
• PubChem化学物质编号: 329817387

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 储存条件: desiccated
• 颜色: off-white
• 溶解性: DMSO: >20 mg/mL
• 创始人: Eli Lilly
• 储存温度: 2-8°C
• SMILES字符串: Cl.COc1ccccc1Oc2ccc(cc2)N(Cc3cccnc3)S(=O)(=O)CC(F)(F)F
• InChI: 1S/C21H19F3N2O4S.ClH/c1-29-19-6-2-3-7-20(19)30-18-10-8-17(9-11-18)26(14-16-5-4-12-25-13-16)31(27,28)15-21(22,23)24;/h2-13H,14-15H2,1H3;1H
• InChI key: LPWFRDWTOKLHJC-UHFFFAOYSA-N

说明

生化/生理作用

LY-487379 is a positive allosteric modulator of the metabotropic glutamate receptor mGluR2.

LY-487379 is a positive allosteric modulator of the metabotropic glutamate receptor mGluR2. EC₅₀ = 1.7 μM. LY-487379 shows no intrinsic agonist or antagonist activity at hmGluR2 and has no activity at human mGluR3. LY-487379 markedly potentiates glutamate-stimulated [35S]GTPγS binding in a concentration-dependent manner at hmGluR2, shifting the glutamate dose-response curve leftward by 3-fold and increasing the maximum levels of [35S]GTPγS stimulation. LY-487379 has anxiolytic effects in fear-potentiated startle. This activity profile is useful in all symptom domains of schizophrenia.

特点和优势

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable