推荐产品
生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
≥98% (SDS-PAGE)
形狀
lyophilized powder
效力
≤0.400 ng/mL EC50
品質
endotoxin tested
分子量
14.9 kDa (containing 129 amino acid residues)
包裝
pkg of 5 and 50 μg
技術
cell culture | mammalian: suitable
雜質
≤1.000 EU/μg
顏色
white
UniProt登錄號
儲存溫度
−20°C
正在寻找类似产品? 访问 产品对比指南
一般說明
白细胞介素-4（IL-4）是一种多效细胞因子，可调节多种 T细胞和B细胞反应，包括将初始 T细胞分化为TH2 表型，促进 B细胞增殖、抗体同种型转换和其他 TH2细胞因子（包括IL-5和IL-9）的表达。1,2 IL-4在过敏性炎症和哮喘的发生中起关键作用。3
IL-4 与两种不同的受体结合；I型受体，由IL-4Rα 链和常见 γ 链组成的异二聚体，γc，和II型受体，IL-4Rα和IL-13Rα的异二聚体。4
天然存在的IL-4分子质量为12-20 kDa。重组人IL-4是含有129个氨基酸残基的14.9kDa蛋白质。人和小鼠 IL-4 具有50％的氨基酸序列同源性，但它们的生物学作用是物种特异性的。5
IL-4 与两种不同的受体结合；I型受体，由IL-4Rα 链和常见 γ 链组成的异二聚体，γc，和II型受体，IL-4Rα和IL-13Rα的异二聚体。4
天然存在的IL-4分子质量为12-20 kDa。重组人IL-4是含有129个氨基酸残基的14.9kDa蛋白质。人和小鼠 IL-4 具有50％的氨基酸序列同源性，但它们的生物学作用是物种特异性的。5
應用
淋巴因子对免疫活性细胞的生长和分化具有明显的影响，抑制 VEGF和βFGF 诱导的血管生成。
外觀
从无菌过滤溶液中冻干。
分析報告
通过剂量依赖性刺激人TF-1细胞的增殖来测量生物活性。
引用
1.Paul, W.E., Interleukin-4: a prototypic immuno-regulatory lymphokine.Blood, 77, 1859-1870 (1991).
2.O′Garra, A., and Arai, N., The molecular basis of T helper 1 and T helper 2 cell differentiation.Trends Cell Biol., 10, 542-550 (2000).
3.Ryan, J.J. et al., Mast cell homeostasis: a fundamental aspect of allergic disease.Crit.Rev. Immunol., 27, 15-32 (2007).
4.Callard, R.E. et al., IL-4 and IL-13 receptors: are they one and the same? Immunol.Today, 17, 108-110 (1996).
5.Yokota, T. et al., Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells.Immunol.Rev., 102, 137-187 (1988).
6.Kitamura, T. et al., Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin.J. Cell Physiol., 140, 323-334 (1989).
2.O′Garra, A., and Arai, N., The molecular basis of T helper 1 and T helper 2 cell differentiation.Trends Cell Biol., 10, 542-550 (2000).
3.Ryan, J.J. et al., Mast cell homeostasis: a fundamental aspect of allergic disease.Crit.Rev. Immunol., 27, 15-32 (2007).
4.Callard, R.E. et al., IL-4 and IL-13 receptors: are they one and the same? Immunol.Today, 17, 108-110 (1996).
5.Yokota, T. et al., Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells.Immunol.Rev., 102, 137-187 (1988).
6.Kitamura, T. et al., Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin.J. Cell Physiol., 140, 323-334 (1989).
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Joshua A Kochanowsky et al.
mBio, 12(2) (2021-03-04)
Polymorphic effector proteins determine the susceptibility of Toxoplasma gondii strains to IFN-γ-mediated clearance mechanisms deployed by murine host cells. However, less is known about the influence of these polymorphic effector proteins on IFN-γ-independent clearance mechanisms. Here, we show that deletion
T Yokota et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(16), 5894-5898 (1986-08-01)
A cDNA sequence coding for a human interleukin has been isolated from a concanavalin A-activated human T-cell cDNA library based on homology with a mouse interleukin cDNA that expresses B-cell stimulatory factor 1 (BSF-1) activity and T-cell- and mast-cell-stimulating activities.
Zhu Wang et al.
Bioengineered, 13(3), 7683-7696 (2022-03-17)
Diabetic nephropathy (DN) is a common complication of diabetes mellitus which can result in renal failure and severely affect public health. Several studies have revealed the important role of podocyte injury in DN progression. Although, the involvement of exosomes derived
Shweta Arora et al.
Cells, 10(8) (2021-08-28)
Macrophage polarization and infiltration to the tumor microenvironment (TME) is a critical determining factor for tumor progression. Macrophages are polarized into two states-M1 (pro-inflammatory, anti-tumorigenic and stimulated by LPS or IFN-γ) and M2 (anti-inflammatory pro-tumorigenic and stimulated by IL-4) phenotypes.
Yen-Kuang Lin et al.
Oxidative medicine and cellular longevity, 2022, 9964689-9964689 (2022-02-01)
Apolipoprotein (a)/lipoprotein(a) (Lp(a)), a major carrier of oxidized phospholipids, and α7-nicotinic acetylcholine receptor (α7-nAChR) may play an important role in the development of coronary artery spasm (CAS). In CAS, the association between Lp(a) and the α7-nAChR-modulated inflammatory macrophage polarization and
商品
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门