跳转至内容
Merck
所有图片(4)

主要文件

HPA038736

Sigma-Aldrich

抗-ANKRD1 兔抗

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

Anti-ALRP, Anti-C-193, Anti-CARP, Anti-CVARP, Anti-MCARP, Anti-ankyrin repeat domain 1 (cardiac muscle)

登录查看公司和协议定价


About This Item

分類程式碼代碼:
12352203
人類蛋白質圖譜編號:

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

產品線

Prestige Antibodies® Powered by Atlas Antibodies

形狀

buffered aqueous glycerol solution

物種活性

human

加強驗證

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

技術

immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:20-1:50

免疫原序列

RYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... ANKRD1(27063)

一般說明

The ankyrin repeat domain 1 (ANKRD1) gene mapped to human 10q23.33, encodes cardiac adriamycin responsive protein (CARP). The encoded nuclear protein is a member of the muscle ankyrin repeat proteins family. Members of this family contain four ankyrin repeats constituting a conserved motif. ANKRD1 is mainly expressed in heart during embryonic and fetal development.

免疫原

ankyrin repeat domain 1 (cardiac muscle) recombinant protein epitope signature tag (PrEST)

應用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

生化/生理作用

Ankyrin repeat domain 1 (ANKRD1) might act as a transcriptional negative regulator for Ventricular myosin light chain-2 (MLC-2v) in cardiac myogenesis. The encoded protein plays a vital role in cardiac muscle function in both physiological and pathological conditions. Additionally, it is also implicated in the regulation of gene expression in the heart. Variations in the gene expression leads to hypertrophic cardiomyopathy (HCM) and human dilated cardiomyopathy. ANKRD1 functions as a transcriptional co-activator and enhances tumor suppressive activity of p53 protein.

特點和優勢

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

聯結

Corresponding Antigen APREST80281

外觀

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律資訊

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

未找到合适的产品?  

试试我们的产品选型工具.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Mapping of porcine ANKRD1, ANKRD2, ANKRD23, VGLL2 and VGLL4 using somatic cell and radiation hybrid panels.
Dong XJ
Animal Genetics, 38, 424-425 (2007)
Assignment of the murine ankyrin-repeated protein gene (Ankrd2) to mouse chromosome 19C3-->D1 and rat chromosome 1q51-->q53 by fluorescence in situ hybridization.
Fujiwara M
Cytogenetic and genome research, 105 (2004)
Mutations in the ANKRD1 gene encoding CARP are responsible for human dilated cardiomyopathy.
Duboscq-Bidot L
European Heart Journal, 30, 2128-2136 (2009)
A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein.
Kojic S
Archives of Biochemistry and Biophysics, 502, 60-67 (2010)
Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy.
Arimura T
Journal of the American College of Cardiology, 54, 334-342 (2009)

Questions

Reviews

No rating value

Active Filters

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门