HPA035015
Anti-STAG1 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-NYD-SP12, Anti-SA-1, Anti-stromal antigen 1
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100 μL
$778.00
$778.00
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100 μL
$778.00
About This Item
$778.00
请联系客服了解存货情况
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生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
产品线
Prestige Antibodies® Powered by Atlas Antibodies
表单
buffered aqueous glycerol solution
种属反应性
human, mouse, rat
增强验证
RNAi knockdown
Learn more about Antibody Enhanced Validation
技术
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200
免疫原序列
TSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSR
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... STAG1(10274)
一般描述
Stromal antigen 1 (STAG1) is a nuclear protein and it is majorly expressed in hematopoietic organs and somatic cells. The gene is located on human chromosome 3q22.3. The protein belongs to the stromal antigen (STAG) subunit of core cohesin complex, that is regulated by PDS5B (PDS5 cohesin associated factor B).
免疫原
stromal antigen 1 recombinant protein epitope signature tag (PrEST)
应用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-STAG1 antibody produced in rabbit has been used in western blotting and immunohistochemistry.
生化/生理作用
Stromal antigen 1 (STAG1) is an important mediator for p53-dependent apoptosis. It is critical for telomeric sister chromatid cohesion in mammalian cells. The protein contributes to a number of pivotal cellular processes, such as transcription, maintenance of chromatin domain architecture and insulator function.
特点和优势
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
联系
Corresponding Antigen APREST79351
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律信息
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
CTCF and cohesinSA-1 mark active promoters and boundaries of repressive chromatin domains in primary human erythroid cells
Steiner LA, et al.
PLoS ONE, 11(5), e0155378-e0155378 (2016)
Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1
Benedetti L, et al.
Oncotarget, 8(23), 37619-37619 (2017)
De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia
Xu B, et al.
Nature Genetics, 44(12), 1365-1365 (2012)
Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway
Anazawa Y, et al.
Oncogene, 23(46), 7621-7621 (2004)
Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair
Kong X, et al.
Molecular and Cellular Biology, 34(4), 685-698 (2014)
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