推荐产品
生物源
chicken
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
rat, human, mouse
製造商／商標名
Genway 15-288-20025F
技術
indirect ELISA: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CSF2(1437)
一般說明
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is also termed as CSF-2. It is a glycoprotein that consists of 127 amino acids. This gene is located on human chromosome 5q31.
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as CSF-2, is encoded by the gene mapped to human chromosome 5q31-33. The encoded protein is expressed in a wide variety of immune cell types, including macrophages, mast cells and T cells, mainly in response to immune activation and inflammatory cytokines. In addition, it is also secreted in various non-immune cell types, such as endothelial cells, keratinocytes and fibroblasts, following the appropriate stimuli.
應用
Anti-GM-CSF antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also suitable for indirect ELISA.
生化／生理作用
GM-CSF (Granulocyte-macrophage colony-stimulating factor) is a pleiotropic cytokine that regulates the growth and differentiation of granulocytes, macrophages, eosinophils and erythrocytes. The gene is present in a cluster along with interleukin-3 (IL-3), IL-4 and IL-5 on chromosome 5.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) facilitates binding of eosinophils to vascular cell adhesion molecule-1 and eosinophil migration into tissues. In addition, it is also implicated in maturation of antigen presenting cells. GM-CSF plays an essential role in modulation of surfactant homeostasis and alveolar macrophage innate immune responses in the lung. It also plays a vital role immune-independent tumor progression. Mutation in the gene is associated with the development of atopic asthma.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is used in the treatment of neutropenia and leukemia in combination with chemotherapies. It plays a major role in proliferation and differentiation of granulocytes and macrophages from bone marrow progenitor cells. GM-CSF also play a vital role in immune regulation and hematopoiesis.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
B H van Leeuwen et al.
Blood, 73(5), 1142-1148 (1989-04-01)
The human genes for the hematopoietic growth factors interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been mapped to 5q23-31. We present in situ hybridization evidence that the human IL-4 gene is located at 5q23.3-31.2, suggesting that the four
Gene-environment interaction effects on the development of immune responses in the 1st year of life.
Sabine Hoffjan et al.
American journal of human genetics, 76(4), 696-704 (2005-02-24)
Asthma is a common disease that results from both genetic and environmental risk factors. Children attending day care in the 1st year of life have lower risks for developing asthma, although the mechanism for this "day care" effect is largely
K Kaushansky et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(10), 3101-3105 (1986-05-01)
Through the use of long single-sequence oligonucleotide probes, the complete gene for human granulocyte-macrophage colony-stimulating factor (hGM-CSF) has been cloned from a human genomic library. The gene is 2.5 kilobases in length, contains three introns, and is present as a
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