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重组
expressed in baculovirus infected Sf9 cells
质量水平
产品线
PRECISIO® Kinase
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
比活
143-193 nmol/min·mg
分子量
~48 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... GSK3B(2932)
一般描述
生化/生理作用
GSK3是一种丝氨酸-苏氨酸蛋白激酶，最初被确定为磷酸化和抑制糖原合成酶的激酶。GSK3普遍存在于人体组织中，并参与多种生理过程的调节，[7]包括胰岛素对糖原和蛋白质合成的控制以及转录因子AP-1和CREB的调节。人类GSK3瞬时转染到稳定转染了各人类tau异构体的中国仓鼠卵巢细胞中，导致tau蛋白在所有被磷酸化依赖性抗tau抗体检测的位点上过度磷酸化。
外形
50 mM 磷酸氢二钠 pH 7.0、300 mm NaCl、150 mm 咪唑、0.1 mM PMSF、0.2 mm DTT、25% 甘油中提供。
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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