推荐产品
生物源
shark (cartilage)
化驗
≥99% (HPLC)
形狀
powder
技術
HPLC: suitable
雜質
≤0.5% Glucosamine (HPAE)
顏色
white to off-white
mp
172-180 °C
溶解度
H2O: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow
儲存溫度
room temp
SMILES 字串
Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
InChI
1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
InChI 密鑰
CBOJBBMQJBVCMW-NQZVPSPJSA-N
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一般說明
D-半乳糖胺（d-GalN）是一种特异性肝毒剂，尤其可在肝细胞内代谢。它是一种源自半乳糖的6碳氨基糖。
應用
D-(+)-半乳糖盐酸盐已用于：
- 甘露聚糖结合凝集素（MBL）与改性云母表面的表面结合
- 腹腔注射前的无菌磷酸盐缓冲液（PBS）中
- 小鼠中产生原发性骨髓来源的巨噬细胞（BMDM）
D-(+)-半乳糖胺（D-软骨胺）联合脂多糖（LPS）已用于诱导急性肝衰竭模型（LPS/D-GALN诱导肝损伤、肝炎）的治疗研究，以寻找新药。
生化／生理作用
半乳糖胺（Gal）通过细胞坏死和凋亡诱导肝细胞死亡。它通过产生尿苷二磷酸己糖胺来阻止肝RNA的产生。D-半乳糖胺可降低细胞内尿嘧啶核苷酸库，进而阻止RNA和蛋白质的产生。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Yating Li et al.
Applied microbiology and biotechnology, 103(1), 375-393 (2018-10-23)
Acute liver failure is a drastic, unpredictable clinical syndrome with high mortality. Various preventive and adjuvant therapies based on modulating the gut flora have been proposed for hepatic injury. We aimed to explore the preventive and therapeutic effects of Bifidobacterium
Xing Lin et al.
Biological & pharmaceutical bulletin, 37(4), 625-632 (2014-05-13)
This study examined the effect of genistein from Hydrocotyle sibthorpioides on lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute hepatic failure. Compared to the model control, genistein treatment significantly protected against LPS/D-GalN-induced liver injury, as evidenced by the decrease in serum alanine and aspartate
Kaicen Wang et al.
mSphere, 5(1) (2020-01-31)
Acute liver failure is a severe liver disorder that poses considerable global challenges. Previous studies on Bifidobacterium longum R0175 have mainly focused on its psychotropic functions. The current research focused on the protective efficacy of B. longum R0175 against acute
Aoxiang Zhuge et al.
Applied microbiology and biotechnology, 104(17), 7437-7455 (2020-07-16)
Acute liver failure is a clinical emergency associated with high mortality. Accumulating evidence indicates that gut microbiota participates in the progression of liver injury, and preventive therapies based on altering gut microbiota are of great interest. Previous studies demonstrated that
Shan-Shan Li et al.
Molecular immunology, 101, 10-18 (2018-06-01)
Acute liver failure is a devastating clinical syndrome with extremely terrible inflammation reaction, which is still lack of effective treatment in clinic. Suppressor of Cytokine Signaling 1 protein is inducible intracellular negative regulator of Janus kinases (JAK)/signal transducers and activators
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