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方案
≥98% (HPLC)
表单
solid
颜色
white to off-white
溶解性
0.1 M NaOH: 10 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma
作用机制
DNA synthesis | interferes
enzyme | inhibits
储存温度
−20°C
SMILES字符串
CN1CCN(CC1)c2c(F)cc3C(=O)C(=CN(CCF)c3c2F)C(O)=O
InChI
1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
InChI key
XBJBPGROQZJDOJ-UHFFFAOYSA-N
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应用
生化/生理作用
Fleroxacin is a synthetic trifluorinated quinolone with antimicrobial activity against a variety of pathogens, including mycobacteria, mycoplasmas, chlamydiae, and legionellae. It strongly inhibits the DNA-supercoiling activity of DNA gyrase and DNA topoisomerase 2, which results in cell death[4].
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
R Steffen et al.
The Journal of antimicrobial chemotherapy, 31(5), 767-776 (1993-05-01)
A double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy and safety of fleroxacin for one or two days as treatment for patients with travellers' diarrhoea. A total of 195 patients who were suffering with acute diarrhoea of less
J C Akaniro et al.
Antimicrobial agents and chemotherapy, 34(10), 1880-1884 (1990-10-01)
We evaluated fleroxacin, a newer fluoroquinolone, against isolates from sputum from patients with cystic fibrosis. These isolates included rough and mucoid Pseudomonas aeruginosa, Pseudomonas cepacia, Staphylococcus aureus, Haemophilus influenzae, and Escherichia coli. Selected isolates were tested by the broth microdilution
R A Blouin et al.
Antimicrobial agents and chemotherapy, 36(3), 632-638 (1992-03-01)
In this open-label study, the disposition of fleroxacin in liver disease in 12 healthy male volunteers, 6 male cirrhotics without ascites (group A), and 6 male cirrhotics with ascites (group B) was evaluated. Fleroxacin (400 mg) was administered orally and
A Pefanis et al.
Antimicrobial agents and chemotherapy, 38(2), 252-255 (1994-02-01)
To assess the potential efficacy of fleroxacin in combination with clindamycin or metronidazole in mixed aerobic and anaerobic infections, we used a rat model of intra-abdominal abscesses in which the inoculum consisted of pooled rat feces mixed with BaSO4. Two
Elisa Fasani et al.
Organic letters, 11(9), 1875-1878 (2009-04-24)
In the cation formed by photoinduced C-F bond cleavage in fleroxacin, intramolecular reaction with the N-ethyl chain is prevented by the electron-withdrawing effect of fluorine and intermolecular attack by nucleophiles is facilitated.
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