所有图片(1)
About This Item
经验公式（希尔记法）:
C24H40ClN5O8
CAS号:
分子量:
562.06
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.56
推荐产品
生物来源
bovine
质量水平
方案
99.5%±0.2%
表单
lyophilized powder
纯化方式
chromatography (and purified by solvent extraction)
储存温度
2-8°C
SMILES字符串
[Cl-].NC(CCCC[n+]1cc(CCC(N)C(O)=O)c(CCCC(N)C(O)=O)c(CCC(N)C(O)=O)c1)C(O)=O
InChI
1S/C24H39N5O8.ClH/c25-17(21(30)31)5-1-2-11-29-12-14(7-9-19(27)23(34)35)16(4-3-6-18(26)22(32)33)15(13-29)8-10-20(28)24(36)37;/h12-13,17-20H,1-11,25-28H2,(H3-,30,31,32,33,34,35,36,37);1H
InChI key
FUPMLZCXPJSGPV-UHFFFAOYSA-N
一般描述
Each vial contains 1 μmole of purified desmosine.
应用
Assays for free or urinary desmosine are often used as markers for disease states characterized by elastin degradation (e.g., emphysema). Conversely, excessive levels of incorporated desmosine are indicators of fibrotic conditions (e.g., cirrhosis).
Desmosine chloride is often used in assays for free or urinary desmosine as markers for disease states characterized by elastin degradation (e.g., emphysema). Elastin degradation has shown strong correlation with vascular calcification, and pretreatment with aluminum ions can inhibit the binding of matrix metalloproteinase (MMP) to elastin.
生化/生理作用
Desmosine is a polyfunctional amino acid that forms cross-links in mature elastin.
注意
极易吸湿
分析说明
Calibrated by UV and amino acid analysis.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Franca Cocci et al.
The international journal of biochemistry & cell biology, 34(6), 594-604 (2002-04-12)
An enhanced proteolysis of lung interstitium is key event in the pathogenesis of emphysema, a major constituent of chronic obstructive pulmonary disease. To assess whether urinary desmosine and/or hydroxyproline may be used as a marker of lung destruction we studied
M Bailey et al.
The American journal of pathology, 159(6), 1981-1986 (2001-12-26)
Calcification of elastin occurs in many pathological cardiovascular diseases including atherosclerosis. We have previously shown that purified elastin when subdermally implanted in rats undergoes severe calcification and aluminum chloride (AlCl(3)) pretreatment of elastin inhibits calcification. In the present study we
Dina M Basalyga et al.
Circulation, 110(22), 3480-3487 (2004-11-17)
Elastin calcification is a widespread feature of vascular pathology, and circumstantial evidence exists for a correlation between elastin degradation and calcification. We hypothesized that matrix metalloproteinase (MMP)-mediated vascular remodeling plays a significant role in elastin calcification. In the present studies
Active Filters
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门
