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主要文件

D7011

Sigma-Aldrich

脱氧核糖核酸 钠盐 来源于人类胎盘

Type XIII

别名:

hpDNA, DNA

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About This Item

CAS号:
MDL编号:
UNSPSC代码:
41106305
NACRES:
NA.51

类型

Type XIII

表单

powder

储存温度

2-8°C

InChI

1S/C15H31N3O13P2/c16-13-1-7(20)11(28-13)5-25-32(21,22)31-9-3-15(18)29-12(9)6-26-33(23,24)30-8-2-14(17)27-10(8)4-19/h7-15,19-20H,1-6,16-18H2,(H,21,22)(H,23,24)

InChI key

AWBASQCACWFTGD-UHFFFAOYSA-N

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一般描述

来自胎盘的脱氧核糖核酸(DNA)及其甲基化规律可以预测胎儿生长异常情况。[1] 怀孕期间吸烟会促进胎盘DNA的甲基化和表观遗传调控。[2]

应用

人胎盘 DNA (hpDNA) 是一种天然 DNA,用于 DNA 结合抗癌剂和调节 DNA 结构和功能的 DNA 结合剂的研究。人胎盘 DNA 也用于溶液中的 DNA 行为物理化学研究。
来自人胎盘的脱氧核糖核酸钠盐已被用于:
  • 作为消化过程优化的标准品,以用于高效液相色谱(HPLC)和质谱[3]
  • 作为紫外(UV)分光光度计测量的标准品[4]
  • 在聚合酶链反应(PCR)分析中用于6型人乳头瘤病毒定量标准曲线的生成[5]

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Results from the NIST 2004 DNA quantitation study
Kline MC, et al.
Journal of Forensic Sciences, 50(3), 1-8 (2005)
DNA methylation in the human placenta and fetal growth
Koukoura O, et al.
Molecular Medicine Reports, 5(4), 883-889 (2012)
Johan S Nilsson et al.
Scientific reports, 9(1), 15432-15432 (2019-10-30)
Nasopharyngeal cancer (NPC) is associated with the Epstein-Barr virus (EBV). The clinical presentation and prognosis of NPC is well described, but not in relation to intralesional EBV-DNA load. In a retrospective design, 48 patients with NPC were examined. Patient history
Viral load and m RNA expression of HPV type 6 among cases with recurrent respiratory papillomatosis
Forslund O, et al.
Laryngoscope, 126(1), 122-127 (2016)
Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy
Morales E, et al.
International Journal of Epidemiology, 45(5), 1644-1655 (2016)

Questions

  1. This item (D7011) has been discontinued. Can you please let me know what the comparable product is?

    1 answer
    1. Product D3035, is a solution of Deoxyribonucleic acid prepared from human placenta at a concentration of 0.05 mg/mL (the 0.1 mg pack size would be 2 mL) and would be the closest equivalent alternative to the discontinued D7011. Please see the link below to review this product:
      https://www.sigmaaldrich.com/product/sigma/d3035

      If a powdered form is preferred we do offer comparable alternatives such as 11691112001 from Roche, Human Genomic DNA from human blood (buffy coat). It is not from human placenta but prepared from 100 to 200 individual blood donors of both sexes (pool of the buffy coat). If the DNA from another species is compatible in your application, products D1626 (from salmon) or D6898 (from herring) are options to consider.

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