所有图片(2)
About This Item
经验公式（希尔记法）:
C12H8ClI
CAS号:
分子量:
314.55
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98%
形狀
powder
mp
278 °C
溶解度
DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
儲存溫度
room temp
SMILES 字串
[Cl-].[I+]1c2ccccc2-c3ccccc13
InChI
1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1
InChI 密鑰
FCFZKAVCDNTYID-UHFFFAOYSA-M
基因資訊
human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)
mouse ... Pik3r1(18708)
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應用
二苯基氯化碘盐可作为NADPH氧化酶(NOX)抑制剂：
- 研究其对活性氧(ROS)浓度的影响，以及对临床恶性胸腔积液(MPE)样本来源中性粒细胞杀伤肿瘤细胞的抑制作用
- 在阿霉素(DOX)+鞭毛蛋白(Flagellin)处理细胞中作为烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶抑制剂，确认炎症变化在活性氧过量后发生
- 作为NOX抑制剂，研究其对肝细胞癌细胞(HepG2)中棕榈酸诱导成球能力的影响
生化／生理作用
一种从巨噬细胞和内皮细胞中提取的一氧化氮合成酶的有效且可逆的抑制剂。也抑制其他黄酮酶，如中性粒细胞NADPH氧化酶。
二亚苯基碘鎓(DPI)可影响线粒体功能。DPI可抑制帕金森病的神经元变性。对局灶性脑缺血具有神经保护作用。DPI可诱导干细胞样肿瘤细胞的化学静息(chemo-quiescence)表型，有效抑制细胞增殖。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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