D2069

Desvenlafaxine Hydrochloride

≥98% (HPLC), powder

• 别名: 4-[2-(Dimethylamino)-1-(1-Hydroxycyclohexyl)Ethyl]-Phenol Hydrochloride
• 经验公式（希尔记法）: C₁₆H₂₅NO₂ · HCl
• CAS号: 300827-87-6
• 分子量: 299.84
• MDL號碼: MFCD11045287
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329798729
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to off-white
• 溶解度: DMSO: >20 mg/mL; H₂O: >20 mg/mL
• 起源: Wyeth
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.CN(C)CC(c1ccc(O)cc1)C2(O)CCCCC2
• InChI: 1S/C16H25NO2.ClH/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1H
• InChI 密鑰: IMWPSXHIEURNKZ-UHFFFAOYSA-N

说明

應用

Desvenlafaxine hydrochloride has been used to evaluate if its occurrence in drinking water at environmental concentrations could induce neuronal gene expression.[1][2]

生化／生理作用

Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor.

Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; K_i = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC₅₀ values of 47 and 531 nM.

Desvenlafaxine hydrochloride is a psychoactive drug. Incidence of this drug in environmental samples might induce in vitro gene expression associated with neurological disorders.[1][2]

特點和優勢

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H319
• 防範說明: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危險分類: Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves