所有图片(2)
About This Item
经验公式（希尔记法）:
C4H13N5O2
CAS号:
分子量:
163.18
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
化驗
≥97% (NMR)
形狀
solid
儲存條件
desiccated
under inert gas
顏色
off-white
溶解度
H2O: >20 mg/mL
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
NCCN(CC[NH3+])N([O-])N=O
InChI
1S/C4H12N5O2/c5-1-3-8(4-2-6)9(11)7-10/h1-6H2/q-1/p+1
InChI 密鑰
PAOXTYJXTPPVHU-UHFFFAOYSA-O
應用
二亚乙基三胺/一氧化氮加合物作为一氧化氮(NO)供体的应用实例：
- 评估NO对绵羊滋养外胚层(oTr1)细胞增殖的直接作用
- 试验其在无巨噬细胞的情况下是否可对MOPC315浆细胞瘤细胞系重新产生NO的生长抑制作用
- 在猪模型中关联NO诱导的房水外流功能（有对照）和外流通路管径变化
生化／生理作用
二亚乙基三胺/一氧化氮加合物(DETA/NO)是一种NONOate（R1R2N-(NO-)-N=O），生成的NO具有最长的体外半寿期。吸入型DETA/NO可用作动物和人类的肺血管扩张剂。这种NO供体在溶液中以可控方式释放一氧化氮。DETA/NO参与蛋白下调和p53表达上调。它可增强p53翻译后修饰，也可下调Nanog和Oct4 mRNA水平。
注意
空气敏感
訊號詞
Danger
危險聲明
危險分類
Self-react. C
儲存類別代碼
5.2 - Organic peroxides and self-reacting hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Susannah Waxman et al.
Investigative ophthalmology & visual science, 59(12), 4886-4895 (2018-10-23)
To correlate outflow function and outflow tract vessel diameter changes induced by nitric oxide (NO). In a porcine anterior segment perfusion model, the effects of a nitric oxide donor (100 μM DETA-NO) on outflow facility were compared with controls (n
Chen Fuh Lam et al.
Clinical and experimental pharmacology & physiology, 30(9), 709-711 (2003-08-28)
1. Inhaled diethylenetriamine nitric oxide adduct (DETA/NO) has been shown to be a selective pulmonary vasodilator in animal and human studies. The aims of the present study were to investigate the effect of DETA/NO on mouse precontracted isolated tracheal smooth
Xiaoqiu Wang et al.
Biology of reproduction, 92(3), 75-75 (2015-02-06)
In mammal species, arginine is a multifunctional amino acid required for survival, growth, and development of conceptuses (embryo/fetus and associated extraembryonic membranes) during the peri-implantation period of pregnancy. However, functional roles of arginine with respect to it being a substrate
Marcela Simontacchi et al.
Plant science : an international journal of experimental plant biology, 183, 159-166 (2011-12-27)
This work was aimed to investigate nitrosyl-Fe complexes formation by reaction of endogenous ligands and Fe, in sorghum embryonic axes exposed to NO-donors. Electron paramagnetic resonance (EPR) was employed to detect the presence of nitrosyl-Fe complexes in plant embryos, as
L De Toni et al.
Journal of endocrinological investigation, 34(10), 738-741 (2012-01-12)
An excess of adipose tissue (AT) in obese individuals is linked to increased cardiovascular risk and mitochondria have been shown to be defective in the muscle and AT of patients with metabolic disorders such as obesity and Type 2 diabetes.
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