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表单
powder
技术
ligand binding assay: suitable
储存温度
−20°C
SMILES字符串
CN(C)c1cccc2c(cccc12)S(=O)(=O)NCC(O)=O
InChI
1S/C14H16N2O4S/c1-16(2)12-7-3-6-11-10(12)5-4-8-13(11)21(19,20)15-9-14(17)18/h3-8,15H,9H2,1-2H3,(H,17,18)
InChI key
QHFXORCWAQTTGH-UHFFFAOYSA-N
应用
Dansylglycine, an HSA drug site II probe, is used for the differentiation and analysis of specific binding sites on serum albumin. Dansylglycine is used to generate chromophore-modified cyclodextrins for use in chemosensor development.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
A Tamura et al.
Journal of pharmaceutical and biomedical analysis, 15(9-10), 1477-1482 (1997-06-01)
Separation process in a liquid chromatographic column were visualized and analyzed by a developed chromato-videoscope. The migration aspects were evaluated with successively obtained densitograms. In reversed-phase chromatography, the band widths of each solute band were almost equal fore both weakly
Laura H Lucas et al.
Journal of the American Chemical Society, 126(43), 14258-14266 (2004-10-28)
It is important to characterize drug-albumin binding during drug discovery and lead optimization as strong binding may reduce bioavailability and/or increase the drug's in vivo half-life. Despite knowing about the location of human serum albumin (HSA) drug binding sites and
M Petersson et al.
Journal of chromatography. B, Biomedical sciences and applications, 714(1), 39-46 (1998-09-24)
This paper describes sample enrichment in a single levitated droplet for capillary electrophoresis (CE) analysis. The droplet was trapped in an acoustical field. The minute sample volumes needed for the enrichment procedure were precisely handled using a piezoelectric flow-through liquid
R Yajima et al.
Journal of chromatography. B, Biomedical applications, 667(2), 333-338 (1995-05-19)
A rapid and sensitive high-performance liquid chromatographic (HPLC)-fluorimetric assay method has been developed for the determination of carboxypeptidase H activity based on the measurement of N-(5-dimethyl-aminonaphthalene-1-sulfonyl)glycine (dansyl-Gly) formed enzymatically from dansyl-Gly-L-Lys or dansyl-Gly-L-Arg. Dansyl-Gly is eluted faster than the substrates
T J Dengler et al.
European journal of clinical pharmacology, 43(5), 491-499 (1992-01-01)
The binding capacity of human serum albumin (HSA) for small acidic molecules is known to be reduced in chronic renal failure (CRF). The contribution of competitive inhibition by accumulated endogenous ligands and of structural changes in HSA has now been
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