Creatine Kinase is a dimer that exists as three isozymes: MM (muscle), MB (hybrid) and BB (brain). Product C9983, Creatine Kinase BB Fraction Human, refers to the brain isozyme.
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一般描述
溶于50%甘油、Tris缓冲液（含10 mM Bis-Tris-HCl、0.5 mM DTT、0.5 mM EDTA）
应用
人肌酸激酶BB部分已被用于研究急性心肌梗死后晚期经皮冠状血管介入治疗对患者的生存益处。人肌酸激酶BB组分也已用于分析蛋白氧化和由此导致的功能损失的研究中。
生化/生理作用
本品用作ELISA法监测脑脊液水平的对照品。肌酸激酶（CK）BB是CK基因家族的成员，是大脑中存在的胞质CK同工型。实测分子量为35-50 kDa。CKs催化ATP和肌酸之间磷酸基的可逆转移。它在神经细胞ATP水平的调节中起重要作用。因此，CK BB活性的降低是与年龄相关的神经退行性疾病（例如阿尔茨海默氏病，皮克氏病和路易体痴呆）中CNS细胞损伤的生化标志之一。[1]
单位定义
一个单位将在37℃下每分钟将1.0 μmole磷酸盐从磷酸肌酸转移至ADP（在340 nm处测量，以偶联反应产生1等摩尔量的NADH计）。
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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T Talvik et al.
Acta paediatrica (Oslo, Norway : 1992), 84(10), 1183-1187 (1995-10-01)
Creatine kinase isoenzyme BB was determined in cerebrospinal fluid (CSF) in 79 preterm neonates using an original enzyme-linked immunosorbent assay. The criterion for inclusion was an Apgar score of 7 or less at 5 min of life. Neurological examination was
M Aksenov et al.
Journal of neurochemistry, 74(6), 2520-2527 (2000-05-23)
Creatine kinase (CK) BB, a member of the CK gene family, is a predominantly cytosolic CK isoform in the brain and plays a key role in regulation of the ATP level in neural cells. CK BB levels are reduced in
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What does the "BB" stand for in "Creatine Kinase BB Fraction Human", product C9983?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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