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product name
L-肌肽, ~99%, crystalline
化驗
~99%
形狀
crystalline
顏色
white to off-white
mp
253 °C (dec.) (lit.)
應用
cell analysis
儲存溫度
−20°C
SMILES 字串
NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(O)=O
InChI
1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
InChI 密鑰
CQOVPNPJLQNMDC-ZETCQYMHSA-N
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Amino Acid Sequence
Ala-His
應用
L-肌肽已可用于研究其作为抗氧化剂对猪肉质量的影响。它还被用于研究其对大鼠脑出血模型中脑损伤的影响。
生化／生理作用
L-肌肽一种二肽，以毫摩尔浓度存在于脑、肌肉和眼睛晶状体中。 在模型系统中，它是一种有效的抗氧化剂，可清除氧自由基和过渡金属离子。 它可以阻断由次氯酸根阴离子以及乙醛、甲醛和丙二醛（脂质过氧化的主要产物）等有毒醛类诱导的蛋白质-蛋白质和蛋白质-DNA交联。 它还能抑制醛糖和酮糖还原糖诱导的非酶促蛋白糖化，并抑制毒性晚期糖基化终产物（AGE）的形成。这些活性使其被用于对衰老、动脉粥样硬化、阿尔茨海默病和糖尿病的继发性影响的研究。
具有强抗氧化性和抗糖化活性的二肽；阻断由反应性醛诱导的非酶促糖基化和蛋白质交联。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Alexander A Boldyrev et al.
Physiological reviews, 93(4), 1803-1845 (2013-10-19)
Carnosine (β-alanyl-l-histidine) was discovered in 1900 as an abundant non-protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal muscle, but also in other excitable tissues. Most animals, except humans, also possess a methylated variant of carnosine
K N Roy Chengappa et al.
Schizophrenia research, 142(1-3), 145-152 (2012-10-27)
Targeting glutamatergic dysfunction provides an exciting opportunity to improve cognitive impairment in schizophrenia. One treatment approach has targeted inadequate antioxidant defenses at glutamatergic synapses. Animal and human data suggest NMDA antagonists worsen executive cognitive controls--e.g. increase perseverative responses and impair
Sanne Stegen et al.
PloS one, 10(3), e0121062-e0121062 (2015-03-25)
Muscle carnosine and its methylated form anserine are histidine-containing dipeptides. Both dipeptides have the ability to quench reactive carbonyl species and previous studies have shown that endogenous tissue levels are decreased in chronic diseases, such as diabetes. Rodent study: Skeletal
T L Dutka et al.
Journal of applied physiology (Bethesda, Md. : 1985), 112(5), 728-736 (2011-12-17)
There is considerable interest in potential ergogenic and therapeutic effects of increasing skeletal muscle carnosine content, although its effects on excitation-contraction (EC) coupling in human muscle have not been defined. Consequently, we sought to characterize what effects carnosine, at levels
The Expression of Carnosine and Its Effect on the Antioxidant Capacity of Longissimus dorsi Muscle in Finishing Pigs Exposed to Constant Heat Stress
Peige Yang
Asian-Australasian Journal of Animal Sciences, 27(12), 1763-1772 (2014)
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