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品質等級
化驗
≥98% (HPLC)
形狀
solid
儲存條件
protect from light
顏色
yellow
溶解度
DMSO: >20 mg/mL
儲存溫度
−20°C
SMILES 字串
O.COc1cc(ccc1O)\C=C\C(=O)c2ccc(Cl)cc2
InChI
1S/C16H13ClO3.H2O/c1-20-16-10-11(3-9-15(16)19)2-8-14(18)12-4-6-13(17)7-5-12;/h2-10,19H,1H3;1H2/b8-2+;
InChI 密鑰
PXVQKTVKTBMRIW-VOKCZWNHSA-N
生化／生理作用
Chalcone 4 is a potent, selective inhibitor of the chemokine CXCL12 via direct binding. It is also a small molecule anti-ligand (or neutraligand) of CXCR4 and CXCR7. The chemokine CXCL12 (stromal cell-derived factor-1) and its receptors play pivotal roles in inflammatory responses, normal vascular and neuronal development, as well as in infectious diseases and cancer. Chalcone 4 binds to and activates the chemokine receptors CXCR4 and CXCR7 and stimulates a rapid receptor-mediated intracellular calcium mobilization and signaling through a Pertussis toxin sensitive Gi protein. Chalcone 4 potently and selectively inhibits CXCL12 binding to CXCR4 and CXCR7, and consequent CXCL12-evoked calcium cellular responses. Chalcone 4 binds to the chemokine CXCL12, but not to its receptors.
特點和優勢
This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
訊號詞
Warning
危險聲明
防範說明
危險分類
Aquatic Acute 1 - Aquatic Chronic 1
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Anna Chi Shan Kam et al.
Journal of medical screening, 21(2), 71-75 (2014-03-14)
To establish the reliability and validity of an automated hearing screening test system for preschoolers and to investigate the risk factors for hearing loss. The study used a cross-sectional design in a comparative study of subjects. The automated hearing screening
Lalita Kulmala et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 37(6), 538-542 (2014-03-14)
The aim of this study was to determine the predictive value of the combination of plasma-soluble fms-like tyrosine kinase 1 (sFlt-1) and uterine artery Doppler for the detection of preeclampsia in women of advanced age at 16-18 weeks of gestation
Susumu Hijioka et al.
Pancreas, 43(3), 367-372 (2014-03-14)
This study investigated whether a risk assessment nomogram can predict the malignant potential of intraductal papillary mucinous neoplasms (IPMNs) and provide valuable information for the follow-up and counseling strategies of such patients. We studied 126 of 589 patients with IPMN
Jie Yu et al.
Chinese medical journal, 127(6), 1039-1045 (2014-03-14)
Many studies have shown that the serum uric acid (SUA) level is one of the cardiovascular risk factors. The aim of the study is to evaluate the relationship between SUA levels and the severity of coronary artery disease (CAD) assessed
Karen Zwaenepoel et al.
Histopathology, 65(4), 539-548 (2014-03-14)
Testing for ALK rearrangements in advanced, non-squamous non-small-cell lung cancers that are wild-type for activating EGFR mutation has become standard care. Fluorescence in-situ hybridization is considered the gold standard for this evaluation. Pre-screening with immunohistochemistry has been suggested, to reduce
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