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化驗
≥90% (HPLC)
形狀
powder
顏色
white
溶解度
DMSO: soluble
儲存溫度
−20°C
SMILES 字串
CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
InChI
1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
InChI 密鑰
QEJRGURBLQWEOU-FKBYEOEOSA-N
基因資訊
human ... PSMA1(5682) , PSMC1(5700)
mouse ... PSMA1(26440) , PSMC1(19179)
rat ... PSMA1(29668) , PSMC1(117263)
Amino Acid Sequence
Z-Leu-Leu-Nva
生化／生理作用
20S蛋白酶体（Ki=21 nM）和26S蛋白酶体（Ki =35 nM）的有效抑制剂。 用54 μM N-CBZ-Leu-Leu-Norvalinal处理的细胞显示完全阻断G1/S和中期转变的，并并延迟通过S期。 可能是通过稳定的p53的积累诱导大鼠-1和PC12细胞中的凋亡。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Raquel M Martinez et al.
Journal of bacteriology, 191(18), 5669-5679 (2009-07-14)
Vibrio cholerae is highly motile by the action of a single polar flagellum. The loss of motility reduces the infectivity of V. cholerae, demonstrating that motility is an important virulence factor. FlrC is the sigma-54-dependent positive regulator of flagellar genes.
U G Lopes et al.
The Journal of biological chemistry, 272(20), 12893-12896 (1997-05-16)
Proteolysis by the ubiquitin/proteasome pathway controls the intracellular levels of a number of proteins that regulate cell proliferation and cell cycle progression. To determine whether this pathway of protein turnover was also linked to apoptosis, we treated Rat-1 and PC12
Gangwei Ou et al.
PloS one, 4(11), e7806-e7806 (2009-11-13)
Vibrio cholerae is the causal intestinal pathogen of the diarrheal disease cholera. It secretes the protease PrtV, which protects the bacterium from invertebrate predators but reduces the ability of Vibrio-secreted factor(s) to induce interleukin-8 (IL-8) production by human intestinal epithelial
Brooke A Jude et al.
Journal of bacteriology, 191(22), 6911-6917 (2009-09-08)
Vibrio cholerae is the etiologic agent of cholera in humans. Intestinal colonization occurs in a stepwise fashion, initiating with attachment to the small intestinal epithelium. This attachment is followed by expression of the toxin-coregulated pilus, microcolony formation, and cholera toxin
Yongjian Qiu et al.
Nature communications, 8(1), 1905-1905 (2017-12-05)
Plant phytochromes are thought to transduce light signals by mediating the degradation of phytochrome-interacting transcription factors (PIFs) through the N-terminal photosensory module, while the C-terminal module, including a histidine kinase-related domain (HKRD), does not participate in signaling. Here we show
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