C5599

Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin

≥95% (HPLC)

• 别名: Cbz-IETD-AFC
• 经验公式（希尔记法）: C₃₇H₄₂F₃N₅O₁₃
• CAS号: 219138-02-0
• 分子量: 821.75
• MDL號碼: MFCD01318832
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329775096

属性

• 化驗: ≥95% (HPLC)
• 形狀: powder
• 儲存溫度: −20°C
• SMILES 字串: CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2
• InChI: 1S/C37H42F3N5O13/c1-4-18(2)30(45-36(56)57-17-20-8-6-5-7-9-20)34(54)42-24(12-13-27(47)48)32(52)44-31(19(3)46)35(55)43-25(16-28(49)50)33(53)41-21-10-11-22-23(37(38,39)40)15-29(51)58-26(22)14-21/h5-11,14-15,18-19,24-25,30-31,46H,4,12-13,16-17H2,1-3H3,(H,41,53)(H,42,54)(H,43,55)(H,44,52)(H,45,56)(H,47,48)(H,49,50)/t18-,19+,24-,25-,30-,31-/m0/s1
• InChI 密鑰: RCIFCAJYIPUCJW-QXPVPWKFSA-N
• 基因資訊: human ... CARD8(22900) , CASP8(841) , CASP8AP2(9994) , CFLAR(8837) , GZMB(3002) ; mouse ... CFLAR(117279) , GZMB(171528) ; rat ... CASP8(12370) , CFLAR(12633) , GZMB(14939) , RGD1561819(502004) , RGD1562700(502007)

说明

Amino Acid Sequence

Z-Ile-Glu-Thr-Asp-AFC

應用

Fluorogenic substrate for caspase 8 and granzyme B.

生化／生理作用

IETD is the sequence of amino acid residues 172-175 of procaspase 3, which is cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

安全信息

• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)