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C3912

Sigma-Aldrich

8-(4-氯苯硫基）-腺苷 3′,5′-环单磷酸 钠盐 钠盐

≥97.0% (HPLC), powder

别名:

pCPT-cAMP

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10 MG
$173.00
50 MG
$396.00
100 MG
$677.00

About This Item

经验公式（希尔记法）:
C16H14ClN5NaO6PS
CAS号:
93882-12-3
分子量:
493.79
EC 号:
299-413-9
MDL编号:
MFCD00057683
UNSPSC代码:
41106305
PubChem化学物质编号:
24278024
NACRES:
NA.77

$173.00

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方案

≥97.0% (HPLC)

表单

powder

颜色

white

溶解性

H2O: 25 mg/mL

储存温度

−20°C

SMILES字符串

[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12

InChI

1S/C16H15ClN5O6PS.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-;/m1./s1

InChI key

YIJFVHMIFGLKQL-DNBRLMRSSA-M

基因信息

human ... PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)

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相关类别

应用

8-（4-硫代氯苯基）腺苷3′5′-环单磷酸用于：
  • 上调细胞胆固醇泵（三磷酸腺苷（ATP）结合盒（ABC）转运蛋白1，ABCA-1）[1]
  • 葡萄糖生成测定[2]
  • 刺激气道上皮细胞的囊性纤维化跨膜传导调节因子（CFTR）通道 [3]

生化/生理作用

膜通透性 cAMP 类似物。用作 cAMP 依赖性蛋白激酶 (PKA) 的选择性激活剂。抑制 cGMP 依赖性磷酸二酯酶，在较高浓度时，抑制 cAMP 依赖性磷酸二酯酶。抑制 n-甲酰-Met-Leu-Phe 刺激的磷酸肌醇水解和分泌，但不抑制白细胞中的血小板活化因子。使 HL-60 细胞更能抵抗 NO 诱导的 DNA 损伤。

特点和优势

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000436362
0000436360
0000436360
0000436362
0000372931

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其他客户在看

Slide 1 of 2

1 of 2

cAMP cAMP used to activate PKA in vitro.

Sigma-Aldrich

20-198

cAMP

ESI-09 ≥98% (HPLC)

Sigma-Aldrich

SML0814

ESI-09

In vitro Methods for the Development and Analysis of Human Primary Airway Epithelia
Gianotti A, et al.
Frontiers in Pharmacology, 9 (2018)
J F Desaphy et al.
The American journal of physiology, 275(6 Pt 1), C1465-C1472 (1998-12-09)
Although the skeletal muscle sodium channel is a good substrate for cAMP-dependent protein kinase (PKA), no functional consequence was observed for this channel expressed in heterologous systems. Therefore, we investigated the effect of 8-(4-chlorophenylthio)adenosine 3',5'-cyclic monophosphate (CPT-cAMP), a membrane-permeable cAMP
Consumption of cuban policosanol improves blood pressure and lipid profile via enhancement of HDL functionality in healthy women subjects: randomized, double-blinded, and placebo-controlled study
Cho KH, et al.
Oxidative Medicine and Cellular Longevity, 2018 (2018)
Aurora Maria Fontainhas et al.
Investigative ophthalmology & visual science, 52(1), 579-587 (2010-09-24)
An early injury response to retinal detachment is disruption of synaptic connectivity between photoreceptors and second-order neurons. Most dramatic is the retraction of rod cell axons and their terminals away from the outer synaptic layer and toward their cell bodies.
B J Connolly et al.
Biochemical pharmacology, 44(12), 2303-2306 (1992-12-15)
8-(4-Chlorophenyl)thio-cyclic AMP (8-CPT-cAMP), extensively used as selective activator of cyclic AMP-dependent protein kinase, has been found to be a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA). Indeed, 8-CPT-cAMP (IC50 = 0.9 microM) inhibited PDE VA with a potency
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Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

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