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Based on our quality control testing, Corticotropin Releasing Factor human, rat (C3042) is soluble in water at a concentration of 1 mg/ml.
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0.1 MG
$465.00
250 μG
$652.00
0.5 MG
$1,610.00
About This Item
经验公式（希尔记法）:
C208H344N60O63S2
CAS号:
分子量:
4757.45
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.32
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Amino Acid Sequence
Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2
一般描述
应用
Corticotropin Releasing Factor human, rat has been used:
- as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants[3]
- as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells[4]
- in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture[5]
- in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus[6]
生化/生理作用
CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Corticotropin-releasing factor modulates stress responses.[7][1] It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.[8]Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders.[9] Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.[10]
Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.
其他说明
Lyophilized from 0.1% TFA in H2O
抗体
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Anxiolytics.
Handbook of Clinical Neurophysiology, 106, 669-669 (2012)
Transcriptional regulation of hypothalamic corticotropin-releasing factor gene
Vitamins & Hormones, 82, 301-317 (2010)
Frameworks of alcohol addiction: alcohol addiction as a reward deficit and stress surfeit disorder
Frontiers in Psychiatry, 3-28 (2014)
A Slominski
The British journal of dermatology, 160(2), 229-232 (2009-02-04)
Corticotropin-releasing hormone (CRH; previously known as corticotropin-releasing factor) is the central regulator of the hypothalamic-pituitary-adrenal (HPA) axis, which is the main organizer of the body’s response to stress.– Stress induces the hypothalamic production and release of CRH, which then causes
Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation
Simard M, et al.
Reproductive Biology and Endocrinology, 8(1), 134-134 (2010)
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What is the solubility of Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
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What is the counter ion in Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
Corticotropin Releasing Factor human, rat (C3042) is lyophilized from 0.1% TFA in water.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the difference between the peptide content and the purity of Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
The peptide content of Corticotropin Releasing Factor human, rat (C3042) is determined by amino acid analysis (AAA) and distinguishes how much of the product is actually peptide. The purity of Corticotropin Releasing Factor human, rat (C3042) is determined by HPLC and distinguishes how much of the peptide found is Corticotropin Releasing Factor human, rat (C3042).
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What is the solution stability of Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
Sigma has not tested Corticotropin Releasing Factor human, rat (C3042) for solution stability or for stability in culture. The following article looks at the stability of corticotropin releasing factor: Acta Med Okayama. 1985 Jun;39(3):199-206.
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