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About This Item
经验公式（希尔记法）:
C10H10BrN5NaO6P
CAS号:
分子量:
430.08
Beilstein:
7739743
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.77
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化驗
≥97% (HPLC)
形狀
powder
顏色
off-white
溶解度
H2O: 100 mg/mL
儲存溫度
−20°C
SMILES 字串
[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Br)nc12
InChI
1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
InChI 密鑰
DMRMZQATXPQOTP-GWTDSMLYSA-M
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相关类别
一般說明
8-溴腺苷3′,5′-环单磷酸是溴化环单核苷酸。
應用
8-溴腺苷3′,5′-环单磷酸钠盐用于：
- 研究其对牛黄体中期细胞fas和caspase-3 mRNA表达以及P4产量的影响
- 用于治疗绒毛膜癌BeWo细胞系，研究其对细胞活力，细胞凋亡和细胞核形态变化的影响
- 在灌注介质中刺激头肾
生化／生理作用
比 cAMP 更抗磷酸二酯酶水解的细胞通透性 cAMP 类似物。激活培养细胞的蛋白激酶 A、抑制生长、减少增殖、增加分化并诱导凋亡。
特點和優勢
该化合物是环核苷酸研究的特色产品。点击此处查看更多特色环核苷酸产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
其他說明
膜渗透性 cAMP 类似物。
注意
对光和水分敏感。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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