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Merck
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文件

B7005

Sigma-Aldrich

倍他米松

≥98%

别名:

9α-氟-11β,17α,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮, 9α-氟-16β-甲基-11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮, 9α-氟-16β-甲基泼尼松龙

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About This Item

经验公式（希尔记法）:
C22H29FO5
CAS号:
378-44-9
分子量:
392.46
EC號碼:
206-825-4
MDL號碼:
MFCD00062969
分類程式碼代碼:
51111800
PubChem物質ID:
57653954
NACRES:
NA.77

生物源

synthetic (organic)

無菌

non-sterile

化驗

≥98%

形狀

powder

mp

235-237 °C (lit.)

溶解度

water: 0.063 g/L at 37 °C

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

InChI 密鑰

UREBDLICKHMUKA-DVTGEIKXSA-N

基因資訊

human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Tnf(21926)
rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)

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相关类别

應用

Betamethasone has been used as a corticosteroid (CORT) standard.

生化／生理作用

Betamethasone, an isomer of dexamethasone is also termed as 9α-fluoro-16β-methyl-11 β,17,21-trihydroxypregna-1,4-dien-3,20-dione or 9α-fluoro-16β-methylprednisolone (27.1.52). It can be used as an anti-itch agent and treating dermatitis and eczema.

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H360FD,H373

危險分類

Repr. 1B - STOT RE 2

標靶器官

Liver,Kidney,Endocrine system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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A versatile liquid chromatography-tandem mass spectrometry system for the analysis of different groups of veterinary drugs.
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Analytica Chimica Acta, 529(1), 137-144 (2005)
Ceá C Tillis et al.
American journal of physiology. Lung cellular and molecular physiology, 300(6), L940-L950 (2011-03-15)
Adequate expression of surfactant protein-B (SP-B) is critical in the function of pulmonary surfactant to reduce alveolar surface tension. Expression of SP-B mRNA is restricted to specific lung-airway epithelial cells, and human SP-B mRNA stability is increased in the presence
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American journal of physiology. Lung cellular and molecular physiology, 304(6), L438-L444 (2013-01-22)
Inflammation and antenatal glucocorticoids, the latter given to mothers at risk for preterm birth, affect lung development and may contribute to the development of bronchopulmonary dysplasia (BPD). The effects of the combined exposures on inflammation and antenatal glucocorticoids on transforming
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A single course of antenatal corticosteroid therapy is recommended for pregnant women at risk of preterm birth between 24 and 33 weeks' gestational age. However, 50% of women remain pregnant 7 to 14 days later, leading to the question of
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