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Merck
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文件

B6311

Sigma-Aldrich

BTO-1

≥98% (HPLC), solid

别名:

5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide

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About This Item

经验公式（希尔记法）:
C9H4N4O4S
CAS号:
40647-02-7
分子量:
264.22
MDL號碼:
MFCD11045282
分類程式碼代碼:
12352200
PubChem物質ID:
329773275
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

solid

顏色

tan

溶解度

H2O: <2 mL/mL
DMSO: ≥5 mg/mL

儲存溫度

2-8°C

SMILES 字串

NC(=O)c1sc2c(cc(cc2[n+]1[O-])C#N)[N+]([O-])=O

InChI

1S/C9H4N4O4S/c10-3-4-1-5-7(6(2-4)13(16)17)18-9(8(11)14)12(5)15/h1-2H,(H2,11,14)

InChI 密鑰

FKRBAXZAJBBIAJ-UHFFFAOYSA-N

生化／生理作用

BTO-1 is a polo-like kinase (Plk) inhibitor.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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Keiko Yata et al.
Molecular cell, 45(3), 371-383 (2012-02-14)
Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusive. Here, we report that Polo-like kinase 1 (Plk1)
Campbell McInnes et al.
Nature chemical biology, 2(11), 608-617 (2006-10-10)
Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and for developing antitumor agents. Guided by homology modeling of the Plk1
Mark E Burkard et al.
PLoS biology, 7(5), e1000111-e1000111 (2009-05-27)
Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation relies on positional cues provided by anaphase spindle
Conrad von Schubert et al.
PLoS biology, 8(9) (2010-10-12)
The protozoan parasite Theileria inhabits the host cell cytoplasm and possesses the unique capacity to transform the cells it infects, inducing continuous proliferation and protection against apoptosis. The transforming schizont is a multinucleated syncytium that resides free in the host
Kristin P Leister et al.
Current chemical genomics, 5, 21-29 (2011-06-07)
Tumor Necrosis Factor-α (TNF-α), a secreted cytokine, plays an important role in inflammatory diseases and immune disorders, and is a potential target for drug development. The traditional assays for detecting TNF-α, enzyme linked immunosorbent assay (ELISA) and radioimmunoassay, are not
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