跳转至内容
Merck
所有图片(1)

主要文件

查看所有文档

B4397

Sigma-Aldrich

缓激肽片断 1-8 乙酸盐 水合物

≥97% (HPLC)

别名:

[des-Arg9]-缓激肽 乙酸盐 水合物

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C44H61N11O10 · xC2H4O2 · yH2O
分子量:
904.02 (anhydrous free base basis)
MDL编号:
MFCD00236892
UNSPSC代码:
12352200
PubChem化学物质编号:
24891773

方案

≥97% (HPLC)

表单

powder

UniProt登记号

P01042

储存温度

−20°C

SMILES字符串

NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(Cc5ccccc5)C(O)=O

InChI

1S/C44H61N11O10/c45-29(15-7-19-48-44(46)47)40(61)55-22-10-18-35(55)42(63)54-21-8-16-33(54)38(59)49-25-36(57)50-30(23-27-11-3-1-4-12-27)37(58)52-32(26-56)41(62)53-20-9-17-34(53)39(60)51-31(43(64)65)24-28-13-5-2-6-14-28/h1-6,11-14,29-35,56H,7-10,15-26,45H2,(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H,64,65)(H4,46,47,48)

InChI key

VCEHWDBVPZFHAG-UHFFFAOYSA-N

基因信息

human ... KNG1 (includes EG:3827)

正在寻找类似产品? 访问 产品对比指南

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe

一般描述

Bradykinin Fragment 1-8, also known as des-Arg9-bradykinin, is produced by the cleavage of bradykinin at 8-9 position by carboxypeptidase N.[1]

应用

Bradykinin Fragment 1-8 acetate salt hydrate has been used as a Bradykinin 1 receptor (B1R) agonist to investigate the expression and the role of B1R, in mediating neuronal injury under the chemical neurotoxicity paradigm in PC12 cell lines.[2] It has also been used as an analyte in nanostructure-initiator mass spectrometry and matrix-assisted laser desorption/ionization (MALDI).[3]

生化/生理作用

Bradykinin Fragment 1-8 is a selective B1 bradykinin receptor agonist.[4] It promotes the release of nitric oxide, prostacyclin, endothelium-derived hyperpolarizing factor in the endothelium. des-Arg9-bradykinin also promotes vasodilatation and increases blood flow in the peripheral circulation.[5]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBB8417V
120M5065
120M5065V
029K5055
100H58206

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

H Naraba et al.
FEBS letters, 435(1), 96-100 (1998-10-02)
In response to bradykinin, phosphorylated MAP kinases (ERK-1 and ERK-2) were abundantly increased in HEK 293 cells, which overexpress the rat B2 kinin receptor. In a similar way des-Arg9-bradykinin stimulation of B1 kinin receptor-overexpressing HEK 293 cells caused activation of
Seok Choi et al.
British journal of pharmacology, 148(7), 918-926 (2006-06-20)
We studied the modulation of pacemaker activities by bradykinin in cultured interstitial cells of Cajal (ICC) from murine small intestine with the whole-cell patch-clamp technique. Externally applied bradykinin produced membrane depolarization in the current-clamp mode and increased tonic inward pacemaker
J F Larrivée et al.
Journal of immunology (Baltimore, Md. : 1950), 160(3), 1419-1426 (1998-05-07)
Several cytokines and LPS regulate the population of the B1 receptors (B1Rs) for kinins; these are responsive to des-Arg9-bradykinin (BK) and Lys-des-Arg9-BK. B1R activation contributes to inflammatory vascular changes and pain. Aortic rings isolated from normal rabbits and incubated in
Amaly Nokkari et al.
PloS one, 10(6), e0128601-e0128601 (2015-06-06)
Traumatic Brain Injury (TBI) is the result of a mechanical impact on the brain provoking mild, moderate or severe symptoms. It is acknowledged that TBI leads to apoptotic and necrotic cell death; however, the exact mechanism by which brain trauma
D Regoli et al.
European journal of pharmacology, 348(1), 1-10 (1998-07-03)
Bradykinin and related kinins act on two receptor types, named B1 and B2. Initially identified in classical bioassays, these receptors have been cloned and characterized in binding assays performed on plasma membranes of cells expressing the native or the transfected
查看所有相关文献

Questions

Reviews

No rating value

Active Filters

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门