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About This Item
经验公式（希尔记法）:
C20H13N3O2
CAS号:
分子量:
327.34
MDL號碼:
分類程式碼代碼:
12352111
PubChem物質ID:
NACRES:
NA.77
推荐产品
生物源
synthetic (organic)
品質等級
化驗
≥98% (TLC)
形狀
solid
顏色
dark red
溶解度
DMSO: soluble
methanol: soluble
儲存溫度
−20°C
SMILES 字串
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c4c[nH]c5ccccc45
InChI
1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
InChI 密鑰
DQYBRTASHMYDJG-UHFFFAOYSA-N
基因資訊
human ... CDK2(1017) , EGFR(1956)
rat ... Prkca(24680)
生化／生理作用
Bisindolylmaleimides (BIM) comprises a group of 11 compounds from BIM-I to BIM-XI. BIMs act as an inhibitor of protein kinase C (PKC). They are derived from staurosporine. BIM IX due to its proapoptotic functionality could be useful in targeting tumor proliferation.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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Ro 31-8220 is a potent protein kinase C (PKC) inhibitor belonging to the chemical class of bisindolylmaleimides (BIMs). Various PKC-independent effects of Ro 31-8220 have however been demonstrated, including inhibition of the ATP-binding cassette drug transporter breast cancer resistance protein.
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