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化驗
>95% (HPLC)
形狀
solid
成份
Peptide content, ~60%
顏色
white
溶解度
H2O: soluble
儲存溫度
−20°C
SMILES 字串
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC[C@@H](NC[C@@H](N)CS)C(C)C)C(O)=O
InChI
1S/C22H38N4O3S2/c1-15(2)20(24-12-17(23)14-30)13-25-19(11-16-7-5-4-6-8-16)21(27)26-18(22(28)29)9-10-31-3/h4-8,15,17-20,24-25,30H,9-14,23H2,1-3H3,(H,26,27)(H,28,29)/t17-,18+,19+,20-/m1/s1
InChI 密鑰
QISLMXIYRQCLIR-FUMNGEBKSA-N
基因資訊
rat ... Fnta(25318)
Amino Acid Sequence
Cys-(R)-Val-(R)-Phe-Met
生化／生理作用
Stable and membrane permeable inhibitor of farnesyltransferase.
包裝
Packaged under nitrogen and with desiccant.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
A Wagle et al.
The Journal of biological chemistry, 273(24), 14968-14974 (1998-06-17)
Glucose-6-phosphate dehydrogenase (G6PDH) controls the flow of carbon through the pentose phosphate pathway and also produces NADPH needed for maintenance of reduced glutathione and reductive biosynthesis. Hepatic expression of G6PDH is known to respond to several dietary and hormonal factors
K Yoshimatsu et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 24(2), 145-155 (1997-01-01)
Posttranslational farnesylation by farnesyltransferase (FTase) is critical for the function of ras oncogene product and FTase has attracted attention as the new target of anticancer agents. B956 and B1352, obtained from the screening of CAAX analog inhibitors of FTase, induced
A M Garcia et al.
The Journal of biological chemistry, 268(25), 18415-18418 (1993-09-05)
The ras protooncogene is involved in regulation of cell growth. Mutations that activate the protein result in uncontrolled cell growth. Ras undergoes a series of posttranslational processing events, the first of which, farnesylation, is crucial for the function of the
Daniel Bakowski et al.
The Journal of physiology, 553(Pt 2), 387-393 (2003-11-05)
In many cell types, the emptying of intracellular Ca2+ stores results in the opening of store-operated Ca2+ channels in the plasma membrane. However, the nature of the signal that couples store content to the opening of these Ca2+ channels is
H Greulich et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 7(11), 1443-1451 (1996-11-01)
The v-crk oncogene, identified as the transforming gene of the CT10 avian sarcoma virus, encodes an adaptor protein capable of transforming chicken embryo fibroblasts (CEFs). Because the Src homology 3 domain of v-Crk is capable of binding the Ras family
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