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生物来源
Vitex trifolia
方案
≥98% (HPLC)
表单
powder
溶解性
ethanol: 1 mg/mL, clear, colorless to light yellow
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
2-8°C
InChI
1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3
InChI key
PJQLSMYMOKWUJG-UHFFFAOYSA-N
一般描述
Casticin is one of the flavonoids present in the traditional Chinese medicine Inula japonica Thunb.[1] It is a polymethyl compound with three rings, a catechol moiety at ortho position, one double bond, two hydroxyl groups, and four methoxy groups. It has been isolated from the fruits, seeds, and leaves of various Vitex species.[2]
应用
Casticin from Vitex trifolia is used to study its mechanisms of action as an antiiflammatory and anticancer agent via processes such as TRAIL-induced apoptosis, cell cycle arrest, ROS generation, and glutathione (GSH) depletion.
生化/生理作用
Casticin has anticancer, pro-apoptotic, anti-proliferative, anti-asthmatic, and anti-angiogenic properties. In addition, it exhibits anti-inflammatory behavior by means of its inhibitory effect on lipoxygenases and T- & B-lymphocytes. Due to its oestrogenic activity, it is being used to manage Premenstrual syndrome in women. It is also reported to mitigate rheumatoid arthritis and liver fibrosis manifestations.[2]
Tubulin-binding anticancer flavonoid. Casticin induces apoptosis in cancer cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Lihua He et al.
Oncology reports, 29(1), 103-108 (2012-10-16)
Casticin, a polymethoxyflavone, has been reported to exert anticancer activities. The objectives of this study were to examine the molecular mechanisms by which casticin induces the growth inhibition and cell cycle arrest in human hepatocellular carcinoma (HCC) cells. The HCC
Flavonoids from the aerial parts of Inula japonica
Qin J, et al.
Chinese Journal of Natural Medicines, 8, 257-259 (2010)
Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells.
Jun Yang et al.
World journal of gastroenterology, 17(38), 4298-4307 (2011-11-18)
To investigate the apoptotic activities of casticin in hepatocellular carcinoma (HCC) cells and its molecular mechanisms. PLC/PRF/5 and Hep G2 cell lines were cultured in vitro and the inhibitory effect of casticin on the growth of cells was detected by
Yuan Hu et al.
The Journal of pharmacy and pharmacology, 59(9), 1307-1312 (2007-09-22)
The ethanol extract of the fruits of Vitex rotundifolia (VRE) and its four major compounds (casticin, luteolin, rotundifuran and agnuside) were tested for their estrogen-like activity by using the modified cell proliferation assay (E-SCREEN assessment system), as well as the
Khadidja Haïdara et al.
Cancer letters, 242(2), 180-190 (2006-01-03)
We studied the mechanism of anti-tumor activity of the flavonoid Casticin, derived from Achillea millefolium. Casticin anti-tumor activity results in cell growth arrest in G2/M and in apoptotic death. As a tubulin-binding agent (TBA), Casticin induces p21, which in turn
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