AV41643

Anti-AGER (AB2) antibody produced in rabbit

IgG fraction of antiserum

• 别名: Anti-Advanced glycosylation end product-specific receptor, Anti-MGC22357, Anti-RAGE
• MDL编号: MFCD06798857
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100
• 偶联物: unconjugated
• 抗体形式: IgG fraction of antiserum
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 分子量: 38 kDa
• 种属反应性: human
• 浓度: 0.5 mg - 1 mg/mL
• 技术: immunohistochemistry: suitable; western blot: suitable
• NCBI登记号: NP_001127
• UniProt登记号: Q15109
• 运输: wet ice
• 储存温度: −20°C
• 靶向翻译后修饰: glycosylation
• 基因信息: human ... AGER(177)

说明

一般描述

The receptor for advanced glycation end products (RAGE or AGER), a member of the immunoglobulin superfamily, is involved in pathologies such as atherosclerosis, micro- and macrovascular diseases, inflammatory diseases and diabetes. RAGE binds advanced glycation end products (AGE) produced by non-enzymatic glycation or glyoxidation of proteins, lipids and nucleic acids.

The previously assigned protein identifier A2BFI7 has been merged into Q15109. Full details can be found on the UniProt database.

特异性

Anti-RAGE (AB2) polyclonal antibody reacts with human advanced glycosylation end product-specific receptor (AGER).

免疫原

Synthetic peptide directed towards the C terminal region of human AGER

应用

Anti-AGER (AB2) polyclonal antibody is used to tag advanced glycation end product receptor protein(s) for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. Anti-AGER (AB2) polyclonal antibody may be used to study the effects/roles of glycation and glyoxidation in cardiovascular disease and diabetes.

生化/生理作用

AGER mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. It is receptor for amyloid beta peptide.This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms.

序列

Synthetic peptide located within the following region: RIRAGNSSPGPGDPGRPGDSRPAHWGHLVAKAATPRRGEEGPRKPGGRGG

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable