价格与库存信息目前不能提供
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
64 kDa
种属反应性
human
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TRIM16(10626)
免疫原
Synthetic peptide directed towards the N terminal region of human TRIM16
生化/生理作用
Tripartite motif containing 16 (TRIM16) is transcriptional repressor belonging to tripartite motif family. It is described as a tumor suppressor protein that interacts with vimentin and E2F1 proteins. It inhibits cell proliferation by inducing cell cycle arrest in G1/S phase in neuroblastoma cells.[1] TRIM16 has the ability to heterodimerize with other TRIM proteins and exhibits E3 ubiquitin ligase activity.[2]
序列
Synthetic peptide located within the following region: PLPRATAQPPAPLSPDSGSPSPDSGSASPVEEEDVGSSEKLGRETEEQDS
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Jessica L Bell et al.
Cell cycle (Georgetown, Tex.), 12(6), 889-898 (2013-02-21)
Neuroblastoma is the most common solid tumor in childhood and represents 15% of all children's cancer deaths. We have previously demonstrated that tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite totif (TRIM) protein family, has significant
Patrick Y Kim et al.
Apoptosis : an international journal on programmed cell death, 18(5), 639-651 (2013-02-14)
TRIM16 exhibits tumour suppressor functions by interacting with cytoplasmic vimentin and nuclear E2F1 proteins in neuroblastoma and squamous cell carcinoma cells, reducing cell migration and replication. Reduced TRIM16 expression in a range of human primary malignant tissues correlates with increased
Jessica L Bell et al.
PloS one, 7(5), e37470-e37470 (2012-05-26)
The TRIM family of proteins is distinguished by its tripartite motif (TRIM). Typically, TRIM proteins contain a RING finger domain, one or two B-box domains, a coiled-coil domain and the more variable C-terminal domains. TRIM16 does not have a RING
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