所有图片(1)
About This Item
经验公式（希尔记法）:
C39H59N7O6 · xC2HF3O2
CAS号:
分子量:
721.93 (free base basis)
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
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方案
≥95% (HPLC)
表单
powder
颜色
white
溶解性
H2O: >1 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
OC(=O)C(F)(F)F.CC(C)C[C@H](N(C)C(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc2ccccc2)C(N)=O
InChI
1S/C39H59N7O6.C2HF3O2/c1-25(2)22-32(45(6)38(51)30(42-27(5)47)20-14-15-21-40)37(50)44-34(26(3)4)39(52)46(7)33(24-29-18-12-9-13-19-29)36(49)43-31(35(41)48)23-28-16-10-8-11-17-28;3-2(4,5)1(6)7/h8-13,16-19,25-26,30-34H,14-15,20-24,40H2,1-7H3,(H2,41,48)(H,42,47)(H,43,49)(H,44,50);(H,6,7)/t30-,31?,32-,33-,34-;/m0./s1
InChI key
FTNLRFFNHYISOF-KOLCXYLVSA-N
Amino Acid Sequence
Ac-Lys-Me-Leu-Val-Me-Phe-Phe-NH2
生化/生理作用
Amyloid β40 fibrillogenesis inhibitor
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
D J Gordon et al.
The journal of peptide research : official journal of the American Peptide Society, 60(1), 37-55 (2002-06-26)
Alzheimer's disease, Huntington's disease and prion diseases are part of a growing list of diseases associated with formation of beta-sheet containing fibrils. In a previous publication, we demonstrated that the self-association of the Alzheimer's beta-amyloid (Abeta) peptide is inhibited by
David J Gordon et al.
Biochemistry, 42(2), 475-485 (2003-01-15)
Protein-protein interactions are frequently mediated by stable, intermolecular beta-sheets. A number of cytokines and the HIV Protease, for example, dimerize through beta-sheet motifs. Evidence also suggests that the macromolecular assemblies of peptides and proteins in amyloid fibrils are stabilized by
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