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Merck
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文件

A5595

Sigma-Aldrich

N-Acetyl-Asp-Gln-Met-Asp-7-amido-4-trifluoromethylcoumarin

≥90% (HPLC), powder

别名:

Ac-DQMD-AFC

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About This Item

MDL號碼:
MFCD03452815
分類程式碼代碼:
12352202
PubChem物質ID:
329770829

化驗

≥90% (HPLC)

形狀

powder

顏色

white

溶解度

DMSO/DMF: 20 mM

儲存溫度

−20°C

SMILES 字串

CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc2c(OC(=O)C=C2C(F)(F)F)c1

InChI

1S/C30H35F3N6O12S/c1-13(40)35-19(11-23(42)43)29(50)37-17(5-6-22(34)41)26(47)38-18(7-8-52-2)27(48)39-20(12-24(44)45)28(49)36-14-3-4-15-16(30(31,32)33)10-25(46)51-21(15)9-14/h3-4,9-10,17-20H,5-8,11-12H2,1-2H3,(H2,34,41)(H,35,40)(H,36,49)(H,37,50)(H,38,47)(H,39,48)(H,42,43)(H,44,45)/t17-,18-,19-,20-/m0/s1

InChI 密鑰

RUWANZFFBSYLMO-MUGJNUQGSA-N

基因資訊

human ... CASP3(836) , CASP6(839)

Amino Acid Sequence

NAc-Asp-Gln-Met-Asp-AFC

應用

Fluorogenic substrate for caspase 3 and 6.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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N J Bump et al.
Science (New York, N.Y.), 269(5232), 1885-1888 (1995-09-29)
The baculovirus antiapoptotic protein p35 inhibited the proteolytic activity of human interleukin-1 beta converting enzyme (ICE) and three of its homologs in enzymatic assays. Coexpression of p35 prevented the autoproteolytic activation of ICE from its precursor form and blocked ICE-induced
D Xue et al.
Nature, 377(6546), 248-251 (1995-09-21)
The baculovirus protein p35 inhibits programmed cell death in such diverse animals as insects, nematodes and mammals. Here we show that p35 protein is a substrate for and inhibitor of the Caenorhabditis elegans cell-death protease CED-3 (refs 6, 7) and

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