所有图片(3)
About This Item
经验公式（希尔记法）:
C8H11N5O3
CAS号:
分子量:
225.20
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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化驗
≥99% (HPLC)
形狀
powder
顏色
white
溶解度
H2O: 0.7 mg/mL
1 M HCl: 50 mg/mL
DMSO: 7 mg/mL
&epsilon ；(消光係數)
11.8 at 256 nm at 1 mM
抗生素活性譜
viruses
作用方式
DNA synthesis | interferes
起源
GlaxoSmithKline
SMILES 字串
NC1=Nc2c(ncn2COCCO)C(=O)N1
InChI
1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
InChI 密鑰
MKUXAQIIEYXACX-UHFFFAOYSA-N
基因資訊
human ... HV1S(3365) , NP(4860)
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一般說明
无环鸟苷或阿昔洛韦是一种鸟苷类似物。
應用
阿昔洛韦作为I型单纯疱疹病毒抑制剂的应用实例：
- 作为阳性对照，通过Vero细胞毒性检测法比较蘑菇提取物的抗病毒活性
- 在感染研究中，检测其对人背根神经节来源神经元(HD10.6)细胞的电压门控钠离子通道(VGSC)的影响
- 检测其对人包皮成纤维细胞的干扰素刺激基因(ISG)表达诱导（Mx1和ISG15）的影响
生化／生理作用
阿昔洛韦是一种抗病毒药，在单纯疱疹病毒胸苷激酶(HSV-TK)的作用下变成三磷酸阿昔洛韦。它竞争性地抑制病毒DNA聚合酶。它对巨细胞病毒和EB(Epstein-Barr)病毒的疗效相对较弱。阿昔洛韦已被用来研究单纯疱疹病毒的潜伏机制。它也具有抗人免疫缺陷型病毒1(HIV-1)活性。
特點和優勢
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
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Cell host & microbe, 4(3), 260-270 (2008-09-10)
For most viruses, there is a need for antimicrobials that target unique viral molecular properties. Acyclovir (ACV) is one such drug. It is activated into a human herpesvirus (HHV) DNA polymerase inhibitor exclusively by HHV kinases and, thus, does not
J J O'Brien et al.
Drugs, 37(3), 233-309 (1989-03-01)
Acyclovir (aciclovir) is a nucleoside antiviral drug with antiviral activity in vitro against members of the herpes group of DNA viruses. As an established treatment of herpes simplex infection, intravenous, oral and to a lesser extent topical formulations of acyclovir
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