跳转至内容
Merck
所有图片(1)

主要文件

查看所有文档

A2263

Sigma-Aldrich

α-天麻素

from Amanita phalloides, ≥85% (HPLC), powder

登录查看公司和协议定价

选择尺寸

1 MG
$472.00

$472.00

请联系客服了解存货情况
获取大包装报价
所有图片(1)

选择尺寸

变更视图
1 MG
$472.00

About This Item

经验公式（希尔记法）:
C39H54N10O14S
CAS号:
23109-05-9
分子量:
918.97
Beilstein:
1071138
EC 号:
245-432-2
MDL编号:
MFCD00215842
UNSPSC代码:
12352202
PubChem化学物质编号:
24890639
NACRES:
NA.32

$472.00

请联系客服了解存货情况
获取大包装报价

生物来源

Amanita phalloides

质量水平

200

方案

≥85% (HPLC)

表单

powder

分子量

918.97  g/mol

颜色

white to light yellow

mp

254-255 °C (lit.)

溶解性

H2O: 1.0 mg/mL

ε (消光系数)

13,500 at 310 nm in H2O at 1 M

储存温度

−20°C

SMILES字符串

CCC(C)C1NC(=O)CNC(=O)C2Cc3c([nH]c4cc(O)ccc34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(N)=O)C(=O)N5CC(O)CC5C(=O)NC(C(C)C(O)CO)C(=O)N2

InChI

1S/C39H54N10O14S/c1-4-16(2)31-36(60)42-11-29(55)43-25-15-64(63)38-21(20-6-5-18(51)7-22(20)46-38)9-23(33(57)41-12-30(56)47-31)44-37(61)32(17(3)27(53)14-50)48-35(59)26-8-19(52)13-49(26)39(62)24(10-28(40)54)45-34(25)58/h5-7,16-17,19,23-27,31-32,46,50-53H,4,8-15H2,1-3H3,(H2,40,54)(H,41,57)(H,42,60)(H,43,55)(H,44,61)(H,45,58)(H,47,56)(H,48,59)

InChI key

CIORWBWIBBPXCG-UHFFFAOYSA-N

正在寻找类似产品? 访问 产品对比指南

Amino Acid Sequence

Asn-Hyp-Hyi-Trp-Gly-Ile-Gly-Cys [Bridge: 4-8]

应用

α-鹅膏毒素已用于：
  • 在免疫荧光测定之前诱导NT2细胞中的转录停滞[1]
  • 诱导小鼠肾组织中的肾毒性[2]
  • 通过细胞活力测定、彗星测定和染色体畸变测定诱导和分析小鼠骨髓细胞的遗传毒性[3]

生化/生理作用

抑制真核细胞RNA聚合酶II和III；不抑制RNA聚合酶I或细菌RNA聚合酶；抑制哺乳动物蛋白合成。
蘑菇的主要有毒成分鬼笔鹅膏可抑制真核细胞RNA聚合酶II和III，但不抑制RNA聚合酶I或细菌RNA聚合酶。抑制哺乳动物蛋白合成。

注意

当避光冷冻保存两年后，通过HPLC可发现保留的样品大于99％。

重悬

以1 mg/ml的分装储备液冻存在-20°C。 反复冻融也不会降解。 仅在使用前再用适当的缓冲液进行稀释。产品会被浓酸或碱所破坏。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H300,H373

危险分类

Acute Tox. 1 Oral - STOT RE 2

靶器官

Kidney,Blood,Liver,Gastrointestinal tract,Respiratory Tract,Central nervous system

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000377163
0000377163
SLCQ3066
SLCK2527
SLCM0429

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Prerna Sethi et al.
Neuroscience letters, 459(2), 100-104 (2009-05-02)
Micro-RNA (miRNA) mediated regulation of messenger RNA (mRNA) complexity in the central nervous system (CNS) is emerging as a critical factor in the control of CNS-specific gene expression during development, plasticity, aging and disease. In these studies, miRNA array and
Davide Carnevali et al.
DNA research : an international journal for rapid publication of reports on genes and genomes, 24(1), 59-69 (2016-12-29)
With more than 500,000 copies, mammalian-wide interspersed repeats (MIRs), a sub-group of SINEs, represent ∼2.5% of the human genome and one of the most numerous family of potential targets for the RNA polymerase (Pol) III transcription machinery. Since MIR elements
Evaluation of the genotoxicity of alpha-amanitin in mice bone marrow cells
Marciniak B, et al.
Toxicon, 137, 1-6 (2017)
Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing.
Kvissel AK, et al.
Experimental Cell Research, 313(13), 2795-2809 (2007)
Ujwal Sheth et al.
Development (Cambridge, England), 137(8), 1305-1314 (2010-03-13)
Germline-specific granules of unknown function are found in a wide variety of organisms, including C. elegans, where they are called P granules. P granules are cytoplasmic bodies in oocytes and early embryos. Throughout most of the C. elegans life cycle
查看所有相关文献

Questions

  1. Can we use this product (alpha amanitin: A2263) to block RNA PII for yeast cell (S. cerevisiae)?

    1 answer

    1. Yes, yeasts are eukaryotic organisms. α-Amanitin inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase.

      Helpful?

Reviews

No rating value

Active Filters

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门