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生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
克隆
4G8, monoclonal
表单
buffered aqueous solution
种属反应性
human
浓度
~1 mg/mL
技术
immunohistochemistry: 1:100-1:1000
immunoprecipitation (IP): 1:10-1:100
indirect ELISA: 1:103-1:105
western blot: 1:100-1:1000
运输
dry ice
储存温度
−20°C
基因信息
human ... APP(351)
免疫原
synthetic peptide corresponding to amino acids 17-24 of the human β amyloid peptide with Glu substituted at position 11, conjugated to KLH.
外形
Solution in phosphate buffered saline.
相关产品
产品编号
说明
价格
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves
Alina Hategan et al.
Nature structural & molecular biology, 24(4), 379-386 (2017-02-22)
Deposition of amyloid-β plaques is increased in the brains of HIV-infected individuals, and the HIV transactivator of transcription (Tat) protein affects amyloidogenesis through several indirect mechanisms. Here, we investigated direct interactions between Tat and amyloid-β peptide. Our in vitro studies
Chunyi Jiang et al.
Analytical and bioanalytical chemistry, 396(5), 1745-1754 (2010-02-06)
Aβ(1-42) is the proteolytic cleavage product of cleavage of the amyloid precursor protein by β- and γ-secretases. The aggregation of Aβ(1-42) plays a causative role in the development of Alzheimer's disease. To lock Aβ(1-42) in a homogenous state, we embedded
M Medecigo et al.
Journal of neuroimmunology, 223(1-2), 104-114 (2010-05-11)
Anti-amyloid immunotherapy has been proposed as an appropriate therapeutic approach for Alzheimer's disease (AD). Significant efforts have been made towards the generation and assessment of antibody-based reagents capable of preventing and clearing amyloid aggregates as well as preventing their synaptotoxic
Stefania Zappettini et al.
Frontiers in pharmacology, 3, 146-146 (2012-08-07)
Using both in vitro (hippocampal synaptosomes in superfusion) and in vivo (microdialysis) approaches we investigated whether and to what extent β amyloid peptide 1-40 (Aβ 1-40) interferes with the cholinergic modulation of the release of glycine (GLY) in the rat
Jason H Y Yeung et al.
Frontiers in neuroscience, 13, 1427-1427 (2020-02-06)
Alzheimer's disease (AD) is the leading type of dementia worldwide. Despite an increasing burden of disease due to a rapidly aging population, there is still a lack of complete understanding of the precise pathological mechanisms which drive its progression. Glutamate
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