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Merck

A0911

Sigma-Aldrich

[Ile7]-血管紧张素 III 乙酸盐 水合物

≥95% (HPLC)

别名:

Arg-Val-Tyr-Ile-His-Pro-Ile

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About This Item

经验公式(希尔记法):
C43H68N12O9 · xC2H4O2 · yH2O
分子量:
897.08 (anhydrous free base basis)
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26

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产品名称

[Ile7]-血管紧张素 III 乙酸盐 水合物, ≥95% (HPLC)

质量水平

方案

≥95% (HPLC)

表单

powder

颜色

white

储存温度

−20°C

SMILES字符串

O.CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)[C@@H](C)CC)C(O)=O

InChI

1S/C43H68N12O9.C2H4O2.H2O/c1-7-24(5)34(40(61)51-31(20-27-21-47-22-49-27)41(62)55-18-10-12-32(55)38(59)54-35(42(63)64)25(6)8-2)53-37(58)30(19-26-13-15-28(56)16-14-26)50-39(60)33(23(3)4)52-36(57)29(44)11-9-17-48-43(45)46;1-2(3)4;/h13-16,21-25,29-35,56H,7-12,17-20,44H2,1-6H3,(H,47,49)(H,50,60)(H,51,61)(H,52,57)(H,53,58)(H,54,59)(H,63,64)(H4,45,46,48);1H3,(H,3,4);1H2/t24-,25-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1

InChI key

YXASJLHKVNKIRW-ZPJCNHGSSA-N

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生化/生理作用

In [Ile7]-Angiotensin III (Ile7-AIII) the seventh amino acid of angiotensin III (phe) is replaced with isoleucine. [Ile7]-Angiotensin III (Ile7 AIII) is an angiotensin III (A III) receptor antagonist used to selectively block the action of Angiotensin III.
[Ile7]-Angiotensin III is (Ile7-Ang III) used as a peptide angiotensin receptor antagonist often in comparison with other Ang antagonists such as saralasin.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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E L Bravo et al.
The Journal of clinical endocrinology and metabolism, 40(3), 530-533 (1975-03-01)
The vascular and steroidogenic responses to (1-Sarcosine, 8-Isoleucine)-, and to (1-Des (Aspartic acid), 8-Isoleucine) angiotensin II were compared in bilaterally nephrectomized, ACTH-suppressed dogs receiving constant infusions of angiotensin II. Aldosterone secretion rate was significantly inhibited by pretreatment with 200 ng/Kg/min
K S Lin et al.
The American journal of physiology, 272(5 Pt 2), H2204-H2210 (1997-05-01)
We evaluated the role of endogenous angiotensin II and III (ANG II and ANG III) at the rostral nucleus reticularis ventrolateralis (NRVL) in the modulation of baroreceptor reflex (BRR) response and the subtype of angiotensin receptors involved in this process.
M L Papouchado et al.
Journal of autonomic pharmacology, 15(1), 1-8 (1995-02-01)
1. Effects of angiotensin III (A III) on 3H-noradrenaline (3H-NA) total, neuronal and non-neuronal uptake, 3H intracellular distribution and release were studied in vitro in the rat hypothalamus. 2. A III (1 microM) decreased total, neuronal and non-neuronal 3H-NA uptake
K L Clark et al.
Journal of cardiovascular pharmacology, 19(4), 515-524 (1992-04-01)
Experiments were performed in anesthetized cats to compare the characteristics of angiotensin receptors in the renal and mesenteric vascular beds. Injection of either angiotensin II (Ang II; 0.3-30 ng) or angiotensin III (Ang III; 0.3-30 ng) directly into the superior
M J Robertson et al.
British journal of pharmacology, 106(1), 166-172 (1992-05-01)
1. Experiments were performed with peptidase inhibitors on rabbit aortic strip preparations, to determine whether endogenous peptidase activity can influence the potency estimates for angiotensin receptor agonists and antagonists in this tissue. 2. Angiotensin II (A II) and angiotensin III

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