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A0550

Sigma-Aldrich

丙氨酸-谷氨酰胺

≥98% (HPLC)

别名:

丙氨酰谷氨酰胺, 丙谷二肽

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1 G
$72.20
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About This Item

经验公式（希尔记法）:
C8H15N3O4
CAS号:
39537-23-0
分子量:
217.22
MDL编号:
MFCD00133046
UNSPSC代码:
12352209
PubChem化学物质编号:
24890433
NACRES:
NA.26

$72.20

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产品名称

丙氨酸-谷氨酰胺, ≥98% (HPLC)

质量水平

200

方案

≥98% (HPLC)

表单

powder

颜色

white to off-white

SMILES字符串

NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O

InChI

1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1

InChI key

HJCMDXDYPOUFDY-WHFBIAKZSA-N

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应用

L-谷氨酰胺是细胞培养的一种必需补充剂。游离氨基酸 L-谷氨酰胺不稳定，通常会降解成焦谷氨酸。丙氨酰-L-谷氨酰胺（Ala-Gln）和 Gylcyl-L-谷氨酰胺（Gly-Gln）用作细胞培养中，作为稳定化 L-谷氨酰胺的替代运输形式。使用 L-丙氨酰谷氨酰胺代替 L-谷氨酰胺的主要优点是它降低了细胞培养过程中产生的氨水平。[1][2]

生化/生理作用

丙氨酰谷氨酰胺是一种在生物制药生产中广泛使用的 L-谷氨酰胺的替代补充剂。丙氨酰谷氨酰胺还可作为抗氧化剂（过氧化物）和抗凋亡（LPS 诱导）因子。Ala-Gln 已被用于研究损伤和败血症，以及研究辐射对体内亮氨酸和蛋白质代谢的影响。[3][4] Ala-Gln 已被用于研究体外多形核白细胞和髓过氧化物酶活性。[5]

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000430402
0000430402
0000417442
0000417418
0000415722

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A Christie et al.
Biotechnology and bioengineering, 64(3), 298-309 (1999-07-09)
Although glutamine is a major carbon source for mammalian cells in culture, its chemical decomposition or cellular metabolism leads to an undesirable excess of ammonia. This limits the shelf-life of glutamine-supplemented media and may reduce the cell yield under certain
J Mühling et al.
Amino acids, 22(1), 39-53 (2002-05-25)
The objective of this study was to determine the effects of arginine, L-alanyl-L-glutamine (Ala-Gln) or taurine on polymorphonuclear leucocyte (PMN) free amino acid profiles, superoxide anion (O2-) generation, hydrogen peroxide (H2O2) formation and released myeloperoxidase activity (MPO). Arginine led to
John D Biggers et al.
Reproductive biomedicine online, 9(1), 59-69 (2004-07-20)
A comparison of the effects of replacing L -glutamine with either glycyl-L-glutamine or alanyl-L-glutamine in a KSOM-type medium on the development of mouse preimplantation embryos in vitro has been made. Alanyl-L-glutamine has no significant effect on the rates of blastocyst
G Biolo et al.
Nutrition (Burbank, Los Angeles County, Calif.), 13(9 Suppl), 52S-57S (1997-09-18)
The metabolic response to trauma and sepsis involves an increased loss of body proteins. Specific sites of changes of protein and amino acid metabolism have been identified. In skeletal muscle, the rate of proteolysis is accelerated greatly. The rate of
M Holecek et al.
Amino acids, 22(1), 95-108 (2002-05-25)
The mechanism by which glutamine produces a favorable effect in the treatment of sepsis, injury, burns and abdominal irradiation is not completely understood. The main aim of this study was to evaluate the effect of alanyl-glutamine (AlaGln) administration on the
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