生物来源
human
质量水平
重组
expressed in NSO cells
方案
>90% (SDS-PAGE)
表单
lyophilized powder
分子量
50-55 kDa by SDS-PAGE (reducing)
calculated mol wt ~37.3 kDa
包装
pkg of 100 μg
储存条件
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... ACVRL1(94)
1 of 4
此商品 | B2929 | E0528 | I5403 |
|---|---|---|---|
| recombinant expressed in NSO cells | recombinant expressed in E. coli | recombinant expressed in NSO cells | recombinant expressed in NSO cells |
| assay >90% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay >90% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| biological source human | biological source human | biological source human | biological source human |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
生化/生理作用
ALK-1 is a type I complex of the serine/threonine kinases. Type I and II receptors bind ligands in the TGF-β superfamily. Human and mouse ALK-1 share approximately 71% amino acid sequence identity in their extracellular domains.
Type I complex of the serine/threonine kinases; bind ligands in the TGF-β superfamily.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
分析说明
Can be used as a calibrator for ALK-1 antibodies.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
A Lux et al.
The Journal of biological chemistry, 274(15), 9984-9992 (1999-04-03)
Germ line mutations in one of two distinct genes, endoglin or ALK-1, cause hereditary hemorrhagic telangiectasia (HHT), an autosomal dominant disorder of localized angiodysplasia. Both genes encode endothelial cell receptors for the transforming growth factor beta (TGF-beta) ligand superfamily. Endoglin
P ten Dijke et al.
Oncogene, 8(10), 2879-2887 (1993-10-01)
Human cDNA clones encoding four novel putative transmembrane protein serine/threonine kinases, denoted activin receptor-like kinase (ALK) -1, -2, -3 and -4, were obtained using a polymerase chain reaction (PCR)-based strategy. The PCR primers were designed based upon the sequence similarity
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