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质量水平
方案
≥98% (HPLC)
表单
solid
颜色
off-white
溶解性
DMSO: >10 mg/mL
H2O: <2 mg/mL
运输
wet ice
储存温度
2-8°C
SMILES字符串
FC1(F)Oc2ccc(cc2O1)\C=C3/SC(=O)NC3=O
InChI
1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4-
InChI key
SRLVNYDXMUGOFI-YWEYNIOJSA-N
生化/生理作用
AS 604850 is a selective PI3Kγ inhibitor
特点和优势
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Montserrat Camps et al.
Nature medicine, 11(9), 936-943 (2005-08-30)
Phosphoinositide 3-kinases (PI3K) have long been considered promising drug targets for the treatment of inflammatory and autoimmune disorders as well as cancer and cardiovascular diseases. But the lack of specificity, isoform selectivity and poor biopharmaceutical profile of PI3K inhibitors have
Daniela Kovacs et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6302-6321 (2020-03-12)
Bovine colostrum, the first milk secreted by the mammary glands of cows shortly after they have given birth, provides a natural source of bioactive substances helpful to promote tissue development and repair, and to maintain a healthy immune system. Owing
Chatvadee Kornsuthisopon et al.
Scientific reports, 14(1), 6777-6777 (2024-03-22)
Extracellular matrix (ECM) is an intricate structure providing the microenvironment niche that influences stem cell differentiation. This study aimed to investigate the efficacy of decellularized ECM derived from human dental pulp stem cells (dECM_DPSCs) and gingival-derived mesenchymal stem cells (dECM_GSCs)
Hon Yan K Yip et al.
Molecular cell, 80(2), 279-295 (2020-10-17)
The PTEN tumor suppressor controls cell death and survival by regulating functions of various molecular targets. While the role of PTEN lipid-phosphatase activity on PtdIns(3,4,5)P3 and inhibition of PI3K pathway is well characterized, the biological relevance of PTEN protein-phosphatase activity
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Discover Bioactive Small Molecules for Kinase Phosphatase Biology
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