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方案
≥98% (TLC)
表单
powder
旋光性
[α]/D +9.5±1.0°, c = 1 in 1 M HCl
组成
carbon, 39.5-41.1%
nitrogen, 11.5-12.0%
颜色
white
mp
204 °C
SMILES字符串
CN[C@@H](CO)C(O)=O
InChI
1S/C4H9NO3/c1-5-3(2-6)4(7)8/h3,5-6H,2H2,1H3,(H,7,8)/t3-/m0/s1
InChI key
PSFABYLDRXJYID-VKHMYHEASA-N
生化/生理作用
N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease[1], neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue. N-Methyl-L-serine stimulates hyaluronan production in human skin fibroblasts[2].
N-Methyl-L-serine has been found to stimulate production of high molecular mass hyaluronan in human fibroblasts. This effect was specific to methylated L-serine and not observed with other methylated amino acids. [2]
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
N-Methyl-L-serine stimulates hyaluronan production in human skin fibroblasts.
Sakai, S., et al.
Skin Pharmacology and Physiology, 12, 276-283 (1999)
Péter Nemes et al.
Journal of mass spectrometry : JMS, 40(1), 43-49 (2004-12-08)
The association properties of natural and non-natural amino acids were studied in detail using electrospray ionization mass spectrometry. The results show a highly diverse cluster formation behavior of amino acids. There are differences regarding the degree of clustering (average cluster
D J Gordon et al.
Biochemistry, 40(28), 8237-8245 (2001-07-11)
A potential goal in the prevention or therapy of Alzheimer's disease is to decrease or eliminate neuritic plaques composed of fibrillar beta-amyloid (Abeta). In this paper we describe N-methyl amino acid containing congeners of the hydrophobic "core domain" of Abeta
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