推荐产品
生物源
mouse
品質等級
100
500
共軛
unconjugated
抗體表格
culture supernatant
抗體產品種類
primary antibodies
無性繁殖
MRQ-69, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions
形狀
buffered aqueous solution
物種活性
human
包裝
vial of 0.1 mL concentrate (481M-94)
vial of 0.1 mL concentrate Research Use Only (481M-94-RUO)
vial of 0.5 mL concentrate (481M-95)
vial of 1.0 mL concentrate (481M-96)
vial of 1.0 mL concentrate Research Use Only (481M-96-RUO)
vial of 1.0 mL pre-dilute Research Use Only (481M-97-RUO)
vial of 1.0 mL pre-dilute ready-to-use (481M-97)
vial of 7.0 mL pre-dilute ready-to-use (481M-98)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (481M-98-RUO)
製造商／商標名
Cell Marque™
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200 (concentrated)
同型
IgG
控制
Ewing’s sarcoma, rhabdomyosarcoma
運輸包裝
wet ice
儲存溫度
2-8°C
視覺化
nuclear
一般說明
The paired-box (PAX) family of proteins are key transcriptional regulators involved in early critical development.1 The PAX-7 transcription factor has important functions in mammalian myogenesis and early neural development, with a particularly crucial role in specification and self-renewal of skeletal muscle tissue.2,3 The expression of PAX-7 is highly restricted in normal adult tissues as demonstrated by nuclear immunoreactivity only being identified in rare, scattered satellite cells of the skeletal muscle and absent in both visceral smooth muscle and cardiac muscle as well as in a broad anatomical range of other non-neoplastic tissues. The assessment of soft tissue tumors and small round cell tumors is a persistent diagnostic challenge because of overlapping morphological features and insufficient molecular characterization in these groups of neoplasms. A high frequency of strong PAX-7 nuclear expression has been identified predominantly in rhabdomyosarcomas, preferentially in the embryonal subtype, and Ewing′s sarcoma, with reactivity being absent in related malignancies such as leiomyosarcoma, lymphoblastic lymphoma, neuroblastoma, carcinoid tumor, gastrointestinal stromal tumor, and small cell lung carcinoma. Immunohistochemical detection of PAX-7 protein can be used as a tool in distinguishing embryonal rhabdomyosarcoma and Ewing′s sarcoma from histologic mimics.4,5
品質
United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO
Canada - RUO
European Union - IVD
Japan - RUO
外觀
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
準備報告
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Note: This requires a keycode which can be found on your packaging or product label.
Download the latest released IFU
Note: This IFU may not apply to your specific product lot.
其他說明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律資訊
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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A Kawakami et al.
Mechanisms of development, 66(1-2), 119-130 (1997-08-01)
We describe here the isolation of chicken PAX6 and PAX7 as members of the PAX gene family expressed in late stages of chick nervous system development. By generating monoclonal antibodies against these PAX molecules, we analyzed their protein distributions in
Hugo C Olguin et al.
Developmental biology, 275(2), 375-388 (2004-10-27)
Satellite cells are myogenic precursors responsible for skeletal muscle regeneration. Satellite cells are absent in the Pax-7-/- mouse, suggesting that this transcription factor is crucial for satellite cell specification [Seale, P., Sabourin, L.A., Girgis-Gabardo, A., Mansouri, A., Gruss, P., Rudnicki
Judith A Blake et al.
Development (Cambridge, England), 141(4), 737-751 (2014-02-06)
Pax genes encode a family of transcription factors that orchestrate complex processes of lineage determination in the developing embryo. Their key role is to specify and maintain progenitor cells through use of complex molecular mechanisms such as alternate RNA splice
Shunichi Toki et al.
Histopathology, 73(4), 645-652 (2018-06-20)
Ewing sarcoma is a small round cell tumour that affects bone and soft tissues. Although the detection of the specific fusion gene is a robust method of its diagnosis, immunohistochemistry may serve as a practical surrogate. Recent tissue microarray studies
Gregory W Charville et al.
The American journal of surgical pathology, 40(10), 1305-1315 (2016-08-16)
Rhabdomyosarcoma, the most common soft tissue malignancy of childhood, is a morphologically variable tumor defined by its phenotype of skeletal muscle differentiation. The diagnosis of rhabdomyosarcoma often relies in part on the identification of myogenic gene expression using immunohistochemical or
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