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Merck

04632

Sigma-Aldrich

N-甲基-L-酪氨酸

≥98% (HPLC)

别名:

(S)-3-(4-Hydroxyphenyl)-2-(methylamino)propionic acid, N-Me-Tyr-OH, Surinamine

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About This Item

经验公式(希尔记法):
C10H13NO3
CAS号:
分子量:
195.22
Beilstein:
2646795
EC號碼:
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:

化驗

≥98% (HPLC)

形狀

powder or crystals

光學活性

[α]/D +16.0±1.0°, c = 1 in 1 M HCl

成份

carbon, 60.7-62.3%
nitrogen, 6.9-7.5%

顏色

colorless to white

應用

cell analysis

SMILES 字串

CN[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C10H13NO3/c1-11-9(10(13)14)6-7-2-4-8(12)5-3-7/h2-5,9,11-12H,6H2,1H3,(H,13,14)/t9-/m0/s1

InChI 密鑰

AXDLCFOOGCNDST-VIFPVBQESA-N

應用

N-Methyl-L-tyrosine was used in experiments as a control group to show that methylation of the imino group in N-p-phenylpropionyl-L-tyrosine eliminates its inhibitory effect on the firing of the giant neurone of the giant African snail.

生化/生理作用

N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease, neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

防範說明

危險分類

Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Y Ariyoshi et al.
British journal of pharmacology, 77(4), 631-639 (1982-12-01)
1 Inhibitory effects of N-beta-phenylpropionyl-L-tyrosine, N-beta-phenylpropionyl-L-tryptophan and their derivatives on an identifiable giant neurone, TAN (tonically autoactive neurone) of an African giant snail (Achatina fulica Férussac) were examined in an attempt to elucidate which structural features are necessary to produce
D J Gordon et al.
Biochemistry, 40(28), 8237-8245 (2001-07-11)
A potential goal in the prevention or therapy of Alzheimer's disease is to decrease or eliminate neuritic plaques composed of fibrillar beta-amyloid (Abeta). In this paper we describe N-methyl amino acid containing congeners of the hydrophobic "core domain" of Abeta

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