PHR1625

卢非酰胺

Pharmaceutical Secondary Standard; Certified Reference Material

• 别名: Rufinamide, 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide
• 经验公式（希尔记法）: C₁₀H₈F₂N₄O
• CAS号: 106308-44-5
• 分子量: 238.19
• MDL编号: MFCD00865314
• UNSPSC代码: 41116107
• PubChem化学物质编号: 329823517
• NACRES: NA.24

属性

• 等级: certified reference material; pharmaceutical secondary standard
• 质量水平: 300
• Agency: traceable to USP 1606401
• API类: rufinamide
• CofA: current certificate can be downloaded
• 包装: pkg of 500 mg
• 技术: HPLC: suitable; gas chromatography (GC): suitable
• 应用: pharmaceutical (small molecule)
• 包装形式: neat
• 储存温度: 2-30°C
• SMILES字符串: NC(=O)c1cn(Cc2c(F)cccc2F)nn1
• InChI: 1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)
• InChI key: POGQSBRIGCQNEG-UHFFFAOYSA-N
• 基因信息: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

说明

一般描述

Rufinamide is an antiepileptic drug, used as an adjunctive for the treatment of seizures associated with Lennox−Gastaut syndrome.[1] Its mode of action involves prolonging the refractory period of voltage-dependent sodium channels via stabilization of the sodium channel inactive state, thus effectively keeping the ion channels closed.[1]

应用

Rufinamide may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography technique.[1][2]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Broad-spectrum anticonvulsant.

诊断含义

Effective therapy for partial seizures in adults and childhood seizures in Lennox-Gastaut syndrome.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA5294 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全信息

• 象形图: GHS08,GHS07
• 警示用语：: Warning
• 危险声明: H336,H351,H361fd
• 预防措施声明: P202 - P261 - P271 - P280 - P304 + P340 + P312 - P308 + P313
• 危险分类: Carc. 2 - Repr. 2 - STOT SE 3
• 靶器官: Central nervous system
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable