The Loss On Drying (LOD) testing for this product is performed at 60°C, as required by the current monograph for determination of volatiles. This temperature is not high enough to determine the entire water content.
推荐产品
等級
certified reference material
pharmaceutical secondary standard
品質等級
agency
traceable to BP 765
traceable to Ph. Eur. O0150000
traceable to USP 1478505
API 家族
omeprazole
CofA
current certificate can be downloaded
技術
HPLC: suitable
gas chromatography (GC): suitable
應用
forensics and toxicology
pharmaceutical (small molecule)
形式
neat
儲存溫度
2-8°C
SMILES 字串
COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C
InChI
1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
InChI 密鑰
SUBDBMMJDZJVOS-UHFFFAOYSA-N
基因資訊
human ... ATP4A(495) , ATP4B(496)
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一般說明
奥美拉唑是一种苯并咪唑药物，具有抗分泌和抗溃疡等特性。它通常可用于治疗十二指肠溃疡、胃溃疡、返流性食管炎及预防其他酸相关疾病。[1]
用于质量控制的药品二级标准品，可为制药实验室和制造商提供了一种方便且经济的替代方案，用于内部工作标准品的制备。
用于质量控制的药品二级标准品，可为制药实验室和制造商提供了一种方便且经济的替代方案，用于内部工作标准品的制备。
應用
奥美拉唑可用作使用通过高效薄层色谱（HPTLC）测定药物制剂中奥美拉唑含量的参考标准品。[2]
这些二级标准品是经过检验的认证标准物质(CRM)。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他标定应用。
分析報告
这些二级标准品可追溯至USP、EP（PhEur）和BP一级标准品。
其他說明
该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。
腳註
要查看该材料的分析证书示例，请在下面的栏位中输入LRAC0716。这只是一个示例证书，可能不是您收到的批次。
推薦產品
在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。
相關產品
产品编号
说明
价格
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
A validated HPTLC method for determination of ondansetron in combination with omeprazole or rabeprazole in solid dosage form
Raval.B.P, et al.
Indian Journal of Pharmaceutical Sciences, 70(3), 386-386 (2008)
Extractive spectrophotometric determination of omeprazole in pharmaceutical preparations
Bhandage A, et al.
Tropical Journal of Pharmaceutical Research, 8(5), 1133-1142 (2009)
Spectrophotometric determination of omeprazole, lansoprazole and pantoprazole in pharmaceutical formulations
Wahbi AAM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 30(4), 1133-1142 (2002)
A validated normal phase HPLC method for simultaneous determination of drotaverine hydrochloride and omeprazole in pharmaceutical formulation
Topagi SK, et al.
Asian Journal of Pharmaceutical and Clinical Research, 3(1), 20-24 (2010)
Kazuhiro Shiizaki et al.
Molecular pharmacology, 85(2), 279-289 (2013-11-23)
Omeprazole (OME) induces the expression of genes encoding drug-metabolizing enzymes, such as CYP1A1, via activation of the aryl hydrocarbon receptor (AhR) both in vivo and in vitro. However, the precise mechanism of OME-mediated AhR activation is still under investigation. While
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Omeprazole Ref PHR1059-1G I noticed in the purity calculation formula that both loss on drying (LoD) and water content are taken into account. What is the reason for that, knowing LoD also allows to measure water content ?
1 answer-
Helpful?
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What is the solubility of product PHR1059 (CAS 73590-58-6)? Specifically, is it soluble in methanol?
1 answer-
Solubility testing for this product has not been conducted. There is no data available regarding solubility in methanol for this product or related products with the same CAS 73590-58-6. However, for omeprazole product O104 (CAS 73590-58-6), the solubility is as follows: H2O: 0.5 mg/mL, DMSO: >19 mg/mL, ethanol: 4.5 mg/mL.
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