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Merck

I3377

Supelco

异烟肼

analytical standard, ≥99% (TLC)

别名:

4-吡啶羧酸酰肼, INH, 异烟酸肼, 雷米封

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About This Item

经验公式(希尔记法):
C6H7N3O
CAS号:
分子量:
137.14
Beilstein:
119374
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

analytical standard

品質等級

化驗

≥99% (TLC)

技術

HPLC: suitable
gas chromatography (GC): suitable

mp

171-173 °C (lit.)

螢光

λex 360 nm; λem 450 nm (thiol adduct)

抗生素活性譜

mycobacteria

應用

forensics and toxicology
pharmaceutical (small molecule)

格式

neat

SMILES 字串

NNC(=O)c1ccncc1

InChI

1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)

InChI 密鑰

QRXWMOHMRWLFEY-UHFFFAOYSA-N

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一般說明

化学结构式:吡啶
异烟肼是一类具有抗分枝杆菌活性的药物。用于结核病的治疗。

應用

参考产品的检验报告,了解更多关于合适仪器技术的信息。联系技术服务部寻求进一步支持。

生化/生理作用

针对结核菌的抗生素,抑制分枝菌酸的生物合成。由肝脏 N-乙酰转移酶 (NAT) 和 细胞色素 P450 2E1 (CYP2E1) 代谢形成肝毒素。选择性诱导 CYP2E1 的表达。可逆抑制 CYP2C19 和 CYP3A4 的活性,在临床相关浓度下机械性地灭活 CYP1A2、CYP2A6、CYP2C19 和 CYP3A4。

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象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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The reference standard methods for drug susceptibility testing (DST) of M. tuberculosis are very slow to give results, and due to the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis, there is an urgent demand for new, rapid and
Samantha Ellis et al.
Molecular pharmacology, 85(2), 269-278 (2013-11-19)
The rise in drug-resistant strains of Mycobacterium tuberculosis is a major threat to human health and highlights the need for new therapeutic strategies. In this study, we have assessed whether high-affinity iron chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class

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