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DYNA001

Sigma-Aldrich

DyNAbind® DNA-编码片段库

别名:

DNA encoded library, DNA library

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1 EA
$21,270.00

$21,270.00

预计发货时间2025年5月21日详情

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$21,270.00

About This Item

UNSPSC代码:
41105521
NACRES:
NA.22

$21,270.00

预计发货时间2025年5月21日详情

获取大包装报价

表单

pellets

储存温度

−20°C

应用

DNA编码文库（DEL）技术是一种药物发现工具，包含小的DNA条形码化合物（Satz 2018）。DyNAbind片段DEL包含小分子量的化合物。利用片段分子的高配体效率来有效探测靶标′的结合位点并增加发现结合剂的可能性（Murray和Rees 2009，Murray等，2012）。而且，该文库使用DyNAbind′专有的动态文库技术可促进结合剂的优化，不仅可以显示单个片段，还可显示超过370,000种高度多样化结构的连接片段对(Reddavide et al. 2015, Reddavide et al. 2019)。DyNAbind′的专有动态文库技术可对片段对进行改组，以自动优化结合剂的亲和力，并增加发现良好匹配的机会。在混合筛选方法之后，可以对条形码使用下一代测序来确定结合的片段。通过我们的网站进行免费测序数据分析，同时生成结合靶标的片段列表。这些片段可以用作结构起点，以开发更大、更接近药物的化合物。



DyNAbind详情

特点和优势

产品功能和优点：

  • 现成并且价格合理的获取DEL技术
  • 动态片段文库为DEL提供了革命性的方法，从而提供了史无前例的文库和数据质量
  • 高水平的质量控制，每个成分都经过单独纯化和验证，以最大程度地提高数据可靠性和成功率
  • 文库设计中使用的比例法可确保化合物处于有利的片段空间中，并具有良好的配体效率和充足的优化空间（Congreve等，2003； Jhoti等，2013）
  • 在请求服务提供商之前能够在内部执行和验证初始DEL筛选
  • 具有最大多样性的文库，可以针对几乎任何可药物化的靶标进行筛选

产品概览：

  • 基于动态片段的DEL可作为现有筛选技术的替代或补充
  • 经济的现成产品，可以立即使用
  • 5个小瓶，每个小瓶都包含一个实验条件的一次性文库
  • 大多数药物发现实验室均可访问的详细实验方案
  • 专门的分析网站和实验方案，用以识别匹配结果

法律信息

DyNAbind GmbH的产品

此DyNAbind产品（简称本产品）的使用受到欧洲专利EP 3 094 745 B1和EP 3 169 832 B1以及美国、加拿大和日本相应申请中专利的保护。授予购买者将本产品仅用于内部研究用途的权利。此有限使用标签许可证书并未授予购买者任何可将生成的片段或产物用于商业产品或服务的权利。欲知商业权利相关信息，请通过[email protected]联系许可证部门。
DyNAbind is a registered trademark of DyNAbind GmbH

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

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Christopher W Murray et al.
Nature chemistry, 1(3), 187-192 (2009-06-01)
The search for new drugs is plagued by high attrition rates at all stages in research and development. Chemists have an opportunity to tackle this problem because attrition can be traced back, in part, to the quality of the chemical
Francesco V Reddavide et al.
Angewandte Chemie (International ed. in English), 54(27), 7924-7928 (2015-05-28)
Dynamic combinatorial chemistry (DCC) explores the thermodynamic equilibrium of reversible reactions. Its application in the discovery of protein binders is largely limited by difficulties in the analysis of complex reaction mixtures. DNA-encoded chemical library (DECL) technology allows the selection of
The 'rule of three' for fragment-based drug discovery: where are we now?
Harren Jhoti et al.
Nature reviews. Drug discovery, 12(8), 644-645 (2013-07-13)
Alexander L Satz
ACS medicinal chemistry letters, 9(5), 408-410 (2018-05-26)
Use of DNA-encoded libraries (DELs) in the pharmaceutical industry has rapidly increased. We discuss what to expect when you run a DEL screen and contemplate guidelines for library design. Additionally, we consider some visionary work and extrapolate to the future.
A 'rule of three' for fragment-based lead discovery?
Miles Congreve et al.
Drug discovery today, 8(19), 876-877 (2003-10-14)
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商品

Fragment-Based DNA-Encoded Library

Dynamic Library technology in drug discovery delivers reliable results with high chemical diversity, suitable for various targets.

Future of Drug Discovery with DNA Encoded Libraries

DNA encoded libraries (DELs) offer a paradigm shift in drug discovery by leveraging molecular biology and high-throughput screening. DELs offer a full high-throughput screening library in one vial. Along with our DEL data package, machine learning and AI can be utilized to determine even more information on targets.

相关内容

Fragment-Based DNA-Encoded Library for Drug Discovery

Fragment-Based DNA-Encoded Library for Drug Discovery

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    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
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      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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