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46542

α-雌二醇

Name: α-雌二醇
Brand: SIAL

VETRANAL^®, analytical standard

别名:

1,3,5(10)雌甾三烯-3,17α-二醇, 3,17α-二羟基-1,3,5(10)-雌三烯, 雌二醇

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About This Item

经验公式（希尔记法）:

C₁₈H₂₄O₂

CAS号:

57-91-0

分子量:

272.38

EC號碼:

200-354-8

MDL號碼:

MFCD00064144

分類程式碼代碼:

41116107

PubChem物質ID:

329757208

NACRES:

NA.24

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等級

analytical standard

品質等級

200

產品線

VETRANAL^®

光學活性

[α]/D 52.0 to 56.0°, c = 1 in ethanol

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

雜質

≤2.0% water

應用

pharmaceutical (small molecule)

格式

neat

SMILES 字串

[H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1

InChI 密鑰

VOXZDWNPVJITMN-SFFUCWETSA-N

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應用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化／生理作用

雌二醇（称为 α 雌二醇或 17 α 雌二醇）是组织培养中人乳腺癌细胞中的一种具有生物活性的雌激素。17-雌二醇及其选择性受体 ER-X 不属于经典激素/受体内分泌系统，而是属于在发育中和成人大脑中具有重要的自分泌/旁分泌功能的系统。17-雌二醇可能对更年期的激素替代策略以及治疗阿尔茨海默病和缺血性中风等神经退行性疾病具有重大意义。

法律資訊

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

GHS08,GHS09

訊號詞

Danger

危險聲明

H341,H351,H360F,H362,H410

防範說明

P201 - P202 - P260 - P263 - P273 - P308 + P313

危險分類

Aquatic Chronic 1 - Carc. 2 - Lact. - Muta. 2 - Repr. 1A

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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Three patients with ketosis had increased excretion of 3-hydroxyglutarate (21.8-37.9 micromol/mmol creatinine; controls 2.3 +/- 1.6), an indicator of glutaryl-CoA dehydrogenase deficiency (GDHD), which normalized when the patients were nonketotic. Clinical assessment of all three patients and enzyme studies in

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Estrogen is a hormone critical in the development, normal physiology and pathophysiology of numerous human tissues. The effects of estrogen have traditionally been solely ascribed to estrogen receptor alpha (ERalpha) and more recently ERbeta, members of the soluble, nuclear ligand-activated

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17beta-Hydroxysteroid dehydrogenase type 7 (17beta-HSD7) catalyzes the reduction of estrone (E(1)) into estradiol (E(2)) and of dihydrotestosterone (DHT) into 5alpha-androstane-3beta,17beta-diol (3beta-diol), therefore modulating the level of mitogenic estrogens and androgens in humans. By classical and parallel chemistry, we generated several

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α-雌二醇