ABT404

Anti-CAPN6 Antibody

from rabbit, purified by affinity chromatography

• 别名: Calpain-6, Calpain-like protease X-linked, Calpamodulin, CalpM
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• 無性繁殖: polyclonal
• application: IF; IHC; WB
• 物種活性: rat, human
• 技術: immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable

属性

• 生物源: rabbit
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: rat, human
• 技術: immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• UniProt登錄號: Q9Y6Q1
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CAPN6(827)

说明

一般說明

Calpain-6, also known as Calpain-like protease X-linked or Calpamodulin (CalpM) and encoded by the gene name CAPN6 or CALPM, belongs to a well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. CAPN6 is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.

免疫原

Epitope: C-terminus

KLH-conjugated synthetic peptide corresponding to the C-terminus of human CAPN6.

應用

Anti-CAPN6 Antibody is an antibody against CAPN6 for use in western blotting, IHC & immunofluorescence.

Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected CAPN6 in human lung tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected CAPN6 in human lung cells.

Research Category
Cell Structure

Research Sub Category
Cytoskeleton

品質

Evaluated by Western Blotting in rat lung tissue lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected CAPN6 in rat lung tissue lysate.

標靶描述

~75 kDa observed. Uncharacterized bands may be observed in some lysate(s).

外觀

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable