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生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
human, mouse, rat
技術
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... GRIA1(2890)
mouse ... Gria1(14799)
rat ... Gria1(50592)
一般說明
谷氨酸受体（GluRs）是一个多样化的群体，负责介导脊椎动物中枢神经系统中的大多数兴奋性突触传递。它们可以分为离子型或代谢型，并可再根据其激动剂的偏好型（NMDA、AMPA或红藻氨酸）而进一步分类。存在有四种类型的AMPA选择性GluR亚基（GluR1、GluR2、GluR3和GluR4）。不同亚基的四聚体或五聚体组合有助于AMPA受体的功能多样性。AMPA受体可在大多数兴奋性突触中介导快速突触电流，具有以亚型组成为特征的化学计量。控制钙渗透性的关键残基位于孔环区域。在GluR1、GluR3和GluR4中，该位置被一个Gln残基所占据。从突触后膜插入或去除GluR1/GluR4寡聚通道似乎是LTP/LTD活性依赖性的，而GluR2/GluR3寡聚体不断循环。
特異性
该抗体识别GluR1的胞外域。
免疫原
对应于大鼠GluR1胞外域的KLH偶联线性肽。
應用
免疫组化分析：代表性批次的1：1,000 的稀释液在人大脑和人小脑组织中检测到GluR1。
抗GluR1抗体是一种高度特异性的兔多克隆抗体，其靶向GluR1&已在蛋白质印迹& IHC（石蜡）中进行了测试。
品質
通过蛋白质印迹对大鼠脑组织裂解液进行了评估。
蛋白质印迹分析：2.0 µg/mL该抗体在10 µg大鼠脑组织裂解液中检测到GluR1。
蛋白质印迹分析：2.0 µg/mL该抗体在10 µg大鼠脑组织裂解液中检测到GluR1。
標靶描述
观察值〜110 kDa
聯結
替代品：PC246-100UG
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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